Katsani Katerina R, Sakellari Dimitra
1Department of Molecular Biology & Genetics, Democritus University of Thrace, Alexandroupolis, Greece.
2Department of Preventive Dentistry, Periodontology and Implant Biology, School of Dentistry, Aristotle University of Thessaloniki, Thessaloniki, Greece.
J Biol Res (Thessalon). 2019 Dec 12;26:17. doi: 10.1186/s40709-019-0109-7. eCollection 2019 Dec.
In the years of personalized (or precision) medicine the 'omics' methodologies in biomedical sciences-genomics, transcriptomics, proteomics and metabolomics-are helping researchers to detect quantifiable biological characteristics, or biomarkers, that will best define the human physiology and pathologies. Proteomics use high throughput and high efficiency approaches with the support of bioinformatic tools in order to identify and quantify the total protein content of cells, tissues or biological fluids. Saliva receives a lot of attention as a rich biological specimen that offers a number of practical and physiological advantages over blood and other biological fluids in monitoring human health. The aim of this review is to present the latest advances in saliva proteomics for biomedicine.
在个性化（或精准）医学时代，生物医学科学中的“组学”方法——基因组学、转录组学、蛋白质组学和代谢组学——正在帮助研究人员检测可量化的生物学特征或生物标志物，这些特征或标志物将最准确地定义人类生理学和病理学。蛋白质组学在生物信息学工具的支持下，采用高通量和高效的方法，以识别和量化细胞、组织或生物体液中的总蛋白质含量。唾液作为一种丰富的生物样本受到了广泛关注，在监测人类健康方面，它比血液和其他生物体液具有许多实际和生理优势。本综述的目的是介绍唾液蛋白质组学在生物医学方面的最新进展。
