内洛尔牛中ADIPOQ、OLR1和PPARGC1A基因多态性与生长和胴体性状的关联
Association of ADIPOQ, OLR1 and PPARGC1A gene polymorphisms with growth and carcass traits in Nelore cattle.
作者信息
Fonseca Patrícia D da S, de Souza Fábio R P, de Camargo Gregório M F, Gil Fernanda M M, Cardoso Diercles F, Zetouni Larissa, Braz Camila U, Boligon Arione A, Branco Renata H, de Albuquerque Lucia G, Mercadante Maria E Z, Tonhati Humberto
机构信息
Universidade Estadual Paulista (Unesp), Departamento de Zootecnia, Jaboticabal, SP 14884-900, Brazil.
Universidade Federal de Pelotas (UFPel), Departamento de Ecologia, Zoologia e Genética, Pelotas, RS 96010-900, Brazil.
出版信息
Meta Gene. 2015 Mar 6;4:1-7. doi: 10.1016/j.mgene.2015.02.001. eCollection 2015 Jun.
In beef cattle farming, growth and carcass traits are important for genetic breeding programs. Molecular markers can be used to assist selection and increase genetic gain. The ADIPOQ, OLR1 and PPARGC1A genes are involved in lipid synthesis and fat accumulation in adipose tissue. The objective of this study was to identify polymorphisms in these genes and to assess the association with growth and carcass traits in Nelore cattle. A total of 639 animals were genotyped by PCR-RFLP for rs208549452, rs109019599 and rs109163366 in ADIPOQ, OLR1 and PPARGC1A gene, respectively. We analyzed the association of SNPs identified with birth weight, weaning weight, female yearling weight, female hip height, male yearling weight, male hip height, loin eye area, rump fat thickness, and backfat thickness. The OLR1 marker was associated with rump fat thickness and weaning weight (P < 0.05) and the PPARGC1 marker was associated with female yearling weight.
在肉牛养殖中，生长和胴体性状对遗传育种计划很重要。分子标记可用于辅助选择并提高遗传增益。ADIPOQ、OLR1和PPARGC1A基因参与脂肪组织中的脂质合成和脂肪积累。本研究的目的是鉴定这些基因中的多态性，并评估其与内洛尔牛生长和胴体性状的关联。分别通过PCR-RFLP对639头动物的ADIPOQ、OLR1和PPARGC1A基因中的rs208549452、rs109019599和rs109163366进行基因分型。我们分析了所鉴定的单核苷酸多态性与出生体重、断奶体重、一岁龄母牛体重、母牛臀高、一岁龄公牛体重、公牛臀高、眼肌面积、臀部脂肪厚度和背部脂肪厚度之间的关联。OLR1标记与臀部脂肪厚度和断奶体重相关（P < 0.05），PPARGC1标记与一岁龄母牛体重相关。
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