Pan Jullie W, Kuzniecky Ruben I
1 Departments of Neurology and Radiology, University of Pittsburgh School of Medicine, Pittsburgh, USA ; 2 Department of Neurology, NYU School of Medicine, New York, USA.
Quant Imaging Med Surg. 2015 Apr;5(2):313-22. doi: 10.3978/j.issn.2223-4292.2015.01.03.
This review discusses the potential utility of broad based use of magnetic resonance (MR) spectroscopic imaging for human epilepsy and seizure localization. The clinical challenges are well known to the epilepsy community, intrinsic in the variability of location, volumetric size and network extent of epileptogenic tissue in individual patients. The technical challenges are also evident, with high performance requirements in multiple steps, including magnet homogeneity, detector performance, sequence design, speed of acquisition in addition to large territory spectral processing. We consider how MR spectroscopy and spectroscopic imaging has been informative for epilepsy thus far, with specific attention to what is measured, the interpretation of such measurements and technical performance challenges. Examples are shown from medial temporal lobe and neocortical epilepsies are considered from 4T, 7T and most recently 3T.
本综述讨论了广泛应用磁共振（MR）波谱成像进行人类癫痫及癫痫灶定位的潜在效用。癫痫学界对临床挑战熟知已久，即个体患者中致痫组织的位置、体积大小和网络范围存在变异性。技术挑战也很明显，在多个步骤中都有高性能要求，包括磁体均匀性、探测器性能、序列设计、采集速度以及大面积光谱处理。我们考虑了到目前为止MR波谱和波谱成像对癫痫的诊断价值，特别关注所测量的内容、此类测量结果的解释以及技术性能挑战。文中展示了来自内侧颞叶癫痫和新皮质癫痫的例子，并探讨了4T、7T以及最近的3T的情况。
