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本文引用的文献

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Accumulation of N-Acylphosphatidylserines and N-Acylserines in the Frontal Cortex in Schizophrenia.精神分裂症患者额叶皮质中N-酰基磷脂酰丝氨酸和N-酰基丝氨酸的蓄积
Neurotransmitter (Houst). 2014;1(1). doi: 10.14800/nt.263.
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Immunomodulatory lysophosphatidylserines are regulated by ABHD16A and ABHD12 interplay.免疫调节性溶血磷脂酰丝氨酸受ABHD16A和ABHD12相互作用的调控。
Nat Chem Biol. 2015 Feb;11(2):164-71. doi: 10.1038/nchembio.1721. Epub 2015 Jan 12.
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Lipids in cell biology: how can we understand them better?细胞生物学中的脂质：我们如何能更好地理解它们？
Mol Biol Cell. 2014 Jun 15;25(12):1819-23. doi: 10.1091/mbc.E13-09-0516.
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Involvement of phospholipase A/acyltransferase-1 in N-acylphosphatidylethanolamine generation.磷脂酶A/酰基转移酶-1参与N-酰基磷脂酰乙醇胺的生成。
Biochim Biophys Acta. 2013 Dec;1831(12):1690-701. doi: 10.1016/j.bbalip.2013.08.017. Epub 2013 Aug 29.
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N-arachidonoyl-L-serine (AraS) possesses proneurogenic properties in vitro and in vivo after traumatic brain injury.N-花生四烯酰基-L-丝氨酸（AraS）在创伤性脑损伤后具有体外和体内的促神经生成特性。
J Cereb Blood Flow Metab. 2013 Aug;33(8):1242-50. doi: 10.1038/jcbfm.2013.75. Epub 2013 May 22.
6
N-acylation of phosphatidylethanolamine and its biological functions in mammals.磷脂酰乙醇胺的N-酰化作用及其在哺乳动物中的生物学功能。
Biochim Biophys Acta. 2013 Mar;1831(3):652-62. doi: 10.1016/j.bbalip.2012.08.019. Epub 2012 Sep 8.
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Generation of N-acylphosphatidylethanolamine by members of the phospholipase A/acyltransferase (PLA/AT) family.磷脂酶 A/酰基转移酶（PLA/AT）家族成员生成 N-酰基磷脂酰乙醇胺。
J Biol Chem. 2012 Sep 14;287(38):31905-19. doi: 10.1074/jbc.M112.368712. Epub 2012 Jul 23.
8
Structural basis for the acyltransferase activity of lecithin:retinol acyltransferase-like proteins.卵磷脂：视黄醇酰基转移酶样蛋白酰基转移酶活性的结构基础。
J Biol Chem. 2012 Jul 6;287(28):23790-807. doi: 10.1074/jbc.M112.361550. Epub 2012 May 17.
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XCMS Online: a web-based platform to process untargeted metabolomic data.XCMS Online：一个用于处理非靶向代谢组学数据的网络平台。
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10
A genome wide shRNA screen identifies α/β hydrolase domain containing 4 (ABHD4) as a novel regulator of anoikis resistance.全基因组 shRNA 筛选鉴定出 α/β 水解酶结构域包含蛋白 4（ABHD4）是一种新型抗失巢凋亡（anoikis resistance）调节剂。
Apoptosis. 2012 Jul;17(7):666-78. doi: 10.1007/s10495-012-0723-4.

ABHD4调节哺乳动物中枢神经系统中多种类型的N-酰基磷脂。

ABHD4 regulates multiple classes of N-acyl phospholipids in the mammalian central nervous system.

作者信息

Lee Hyeon-Cheol, Simon Gabriel M, Cravatt Benjamin F

机构信息

The Skaggs Institute for Chemical Biology and Department of Chemical Physiology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.

出版信息

Biochemistry. 2015 Apr 21;54(15):2539-49. doi: 10.1021/acs.biochem.5b00207. Epub 2015 Apr 8.

DOI:10.1021/acs.biochem.5b00207
PMID:25853435
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4767004/
Abstract

N-Acyl phospholipids are atypical components of cell membranes that bear three acyl chains and serve as potential biosynthetic precursors for lipid mediators such as endocannabinoids. Biochemical studies have implicated ABHD4 as a brain N-acyl phosphatidylethanolamine (NAPE) lipase, but in vivo evidence for this functional assignment is lacking. Here, we describe ABHD4(-/-) mice and their characterization using untargeted lipidomics to discover that ABHD4 regulates multiple classes of brain N-acyl phospholipids. In addition to showing reductions in brain glycerophospho-NAEs (GP-NAEs) and plasmalogen-based lyso-NAPEs (lyso-pNAPEs), ABHD4(-/-) mice exhibited decreases in a distinct set of brain lipids that were structurally characterized as N-acyl lysophosphatidylserines (lyso-NAPSs). Biochemical assays confirmed that NAPS lipids are direct substrates of ABHD4. These findings, taken together, designate ABHD4 as a principal regulator of N-acyl phospholipid metabolism in the mammalian nervous system.

摘要

N-酰基磷脂是细胞膜的非典型成分，带有三条酰基链，可作为脂质介质（如内源性大麻素）的潜在生物合成前体。生化研究表明ABHD4是一种脑N-酰基磷脂酰乙醇胺（NAPE）脂肪酶，但缺乏该功能归属的体内证据。在此，我们描述了ABHD4基因敲除小鼠及其通过非靶向脂质组学进行的表征，以发现ABHD4调节多种类型的脑N-酰基磷脂。除了脑甘油磷酸-N-酰基乙醇胺（GP-NAEs）和基于缩醛磷脂的溶血-NAPE（lyso-pNAPEs）减少外，ABHD4基因敲除小鼠还表现出一组独特的脑脂质减少，这些脂质在结构上被表征为N-酰基溶血磷脂酰丝氨酸（lyso-NAPSs）。生化分析证实NAPS脂质是ABHD4的直接底物。综合这些发现，确定ABHD4为哺乳动物神经系统中N-酰基磷脂代谢的主要调节因子。