Ray Andrew D, Mahoney Martin C, Fisher Nadine M
a Department of Rehabilitation Science and.
b Department of Epidemiology and Environmental Health, School of Public Health and Health Professions, State University of New York at Buffalo , Buffalo , NY , USA.
Disabil Rehabil. 2015 Dec;37(26):2407-2412. doi: 10.3109/09638288.2015.1031286. Epub 2015 Apr 8.
This article examines the association between measures of respiratory muscle function and fatigue in individuals with mild-to-moderate disability multiple sclerosis (MS).
This was a cross-sectional study of 37 ambulatory volunteers with MS (28 F/9 M, 52.7 ± 10.2 years, Expanded Disability Status Scale [EDSS] = 3.5 ± 1.9). No patients withdrew from the study. Primary outcome variables included measures of respiratory function: maximal inspiratory (MIP) and expiratory pressures (MEP), forced vital capacity (FVC), forced expiratory volume in 1 s (FEV), maximal voluntary ventilation (MVV); and a self-reported measure of fatigue: the Modified Fatigue Impact Scale (MFIS). Secondary measures included 6-min walking test (6MWT), a timed stair climb, the Short Form (SF)-36, the Epworth Sleepiness Scale and the Physical Activity and Disability Scale (PADS).
Significant correlations were shown between expiratory muscle strength (MEP) and the MFIS total (p < 0.03, r = -0.362) and between MEP and physical fatigue scores (p < 0.03, r = -0.360), as well as between MVV percent predicted (respiratory muscle endurance) and both the 6MWT (p = 0.045, r = 0.346) and the Epworth Sleepiness Scale (p = 0.006, r = 0.447).
Respiratory muscle performance is correlated with perceived fatigue (MFIS), whereas respiratory endurance correlated to reductions in physical function and sleep quality among individuals with mild-to-moderate severity MS. Implications for Rehabilitation Multiple sclerosis (MS) results in peripheral and respiratory muscle weakness and affected individuals report fatigue as one of their most disabling symptoms. Expiratory muscle strength was correlated with self-reported physical fatigue, while respiratory muscle endurance was correlated with functional performance and sleepiness. Respiratory muscle strength was not correlated with lung spirometry testing. These findings highlight the importance of considering the effects of respiratory muscle weakness when evaluating causes of fatigue among individuals with mild-to-moderate MS.
本文探讨轻至中度残疾的多发性硬化症（MS）患者呼吸肌功能指标与疲劳之间的关联。
这是一项对37名能行走的MS志愿者的横断面研究（28名女性/9名男性，年龄52.7±10.2岁，扩展残疾状态量表[EDSS]=3.5±1.9）。没有患者退出研究。主要结局变量包括呼吸功能指标：最大吸气压力（MIP）和呼气压力（MEP）、用力肺活量（FVC）、第1秒用力呼气量（FEV）、最大自主通气量（MVV）；以及一项自我报告的疲劳指标：改良疲劳影响量表（MFIS）。次要指标包括6分钟步行试验（6MWT）、定时爬楼梯、简短健康调查问卷（SF-36）、爱泼沃斯嗜睡量表和身体活动与残疾量表（PADS）。
呼气肌力量（MEP）与MFIS总分之间存在显著相关性（p<0.03，r=-0.362），MEP与身体疲劳评分之间也存在显著相关性（p<0.03，r=-0.360），以及预测的MVV百分比（呼吸肌耐力）与6MWT（p=0.045，r=0.346）和爱泼沃斯嗜睡量表（p=0.006，r=0.447）之间均存在显著相关性。
呼吸肌功能与感知疲劳（MFIS）相关，而呼吸耐力与轻至中度严重程度MS患者的身体功能下降和睡眠质量相关。康复意义 多发性硬化症（MS）会导致外周和呼吸肌无力，受影响个体将疲劳报告为最致残的症状之一。呼气肌力量与自我报告的身体疲劳相关，而呼吸肌耐力与功能表现和嗜睡相关。呼吸肌力量与肺功能测试无关。这些发现突出了在评估轻至中度MS患者疲劳原因时考虑呼吸肌无力影响的重要性。
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