Vural Pelin, Akinci Buket, Guler Serhat, Saltik Sema, Yazgan Yonca Zenginler
Department of Physiotherapy and Rehabilitation, Faculty of Health Sciences, Istanbul Medipol University, Istanbul, Turkey.
Department of Physiotherapy and Rehabilitation, Institute of Graduate Studies, Istanbul University-Cerrahpasa, Istanbul, Turkey.
Acta Neurol Belg. 2025 Feb;125(1):69-75. doi: 10.1007/s13760-024-02628-4. Epub 2024 Aug 21.
To compare PwPOMS and healthy controls in terms of respiratory functions, respiratory muscle strength, and fatigue, and investigate the determining role of fatigue on respiratory parameters.
Twenty-five PwPOMS and 15 healthy controls were included in the study. Maximum inspiratory pressure (MIP) and expiratory pressures (MEP) were measured. Respiratory functions were evaluated using spirometry, and predicted values were recorded for FEV1, FVC, FEV1/FVC, and PEF. Fatigue levels were assessed using the Pediatric Quality of Life Inventory Multidimensional Fatigue Scale (PedsQL-MFS).
The FEV1%pred (p = 0.022), PEF%pred (p = 0.003), MIP (p = 0.001), and MEP (p = 0.019), cognitive fatigue self-reported score of PedsQL-MFS (p = 0.037), sleep-rest fatigue (p = 0.034), cognitive fatigue (p = 0.010), and total score (p = 0.005) of PedsQL-MFS Proxy Report were significantly decreased in PwPOMS compared with their healthy peers. Regression analysis showed that the general fatigue of self-reported PedsQL-MFS was a determinator for FEV1%pred (β= -0.467) and PEF% (β= -0.553), and total score PedsQL-MFS was a determinator for FEV1/FVC %pred (β= -0.599).
PwPOMS had decreased respiratory muscle strength, FEV1, and PEF, with preserved FEV1/FVC and higher fatigue levels than their healthy peers. In addition, self-reported fatigue had a determining role in respiratory functions but not respiratory muscle strength in PwPOMS. This trial is registered on ClinicalTrials.gov under "NCT05123924" available at: https://clinicaltrials.gov/ct2/show/NCT05123924 .
比较多发性硬化症患者（PwPOMS）与健康对照者在呼吸功能、呼吸肌力量和疲劳方面的差异，并研究疲劳对呼吸参数的决定性作用。
本研究纳入了25例PwPOMS患者和15名健康对照者。测量最大吸气压力（MIP）和呼气压力（MEP）。使用肺量计评估呼吸功能，并记录第一秒用力呼气容积（FEV1）、用力肺活量（FVC）、FEV1/FVC和呼气峰值流速（PEF）的预测值。使用儿童生活质量量表多维疲劳量表（PedsQL-MFS）评估疲劳水平。
与健康同龄人相比，PwPOMS患者的FEV1%预测值（p = 0.022）、PEF%预测值（p = 0.003）、MIP（p = 0.001）和MEP（p = 0.019）、PedsQL-MFS认知疲劳自评得分（p = 0.037）、睡眠-休息疲劳（p = 0.034）、认知疲劳（p = 0.010）以及PedsQL-MFS代理报告的总分（p = 0.005）均显著降低。回归分析表明，PedsQL-MFS自评的总体疲劳是FEV1%预测值（β = -0.467）和PEF%（β = -0.553）的决定因素，PedsQL-MFS总分是FEV1/FVC%预测值（β = -0.599）的决定因素。
PwPOMS患者的呼吸肌力量、FEV1和PEF降低，FEV1/FVC保持正常，且疲劳水平高于健康同龄人。此外，自评疲劳在PwPOMS患者的呼吸功能中起决定性作用，但对呼吸肌力量无影响。本试验已在ClinicalTrials.gov上注册，注册号为“NCT05123924”，可在https://clinicaltrials.gov/ct2/show/NCT05123924查询。
