Waters D J, Hayden D W, Walter P A
Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul 55108.
J Vet Intern Med. 1989 Oct-Dec;3(4):222-30. doi: 10.1111/j.1939-1676.1989.tb00861.x.
A retrospective analysis of 85 dogs with hemangiosarcoma (HSA) that underwent complete necropsy, including gross examination of the brain, was conducted. Grossly identifiable intracranial lesions were present in 17 dogs. Twelve of 85 dogs (14.2%) had brain metastases. Four of 85 dogs (4.7%) had hemorrhagic lesions and/or ischemic necrosis without identifiable tumor. One dog had a primary central nervous system tumor. Signs of intracranial disease were present in six of 85 dogs (7.1%) with HSA; four had brain metastases and two had nonneoplastic lesions. Metastases had a propensity for cerebrum and gray matter. Dogs with brain metastases had more widely disseminated disease than dogs without brain metastases (P less than 0.001). Dogs with pulmonary metastases were at greater risk for developing brain metastases than dogs without pulmonary metastases (odds ratio = 8.31). Although thoracic radiography accurately identified ten of 12 dogs (83%) with pulmonary metastases, too few cases were available to assess the applicability/accuracy of thoracic radiography in predicting the presence or absence of brain metastases in dogs with malignancy and signs of intracranial disease.
对85只患有血管肉瘤（HSA）且接受了完整尸检（包括脑部大体检查）的犬进行了回顾性分析。17只犬存在肉眼可识别的颅内病变。85只犬中有12只（14.2%）发生脑转移。85只犬中有4只（4.7%）有出血性病变和/或缺血性坏死但无明确肿瘤。1只犬有原发性中枢神经系统肿瘤。85只患有HSA的犬中有6只（7.1%）出现颅内疾病体征；4只发生脑转移，2只患有非肿瘤性病变。转移瘤倾向于发生在大脑和灰质。发生脑转移的犬比未发生脑转移的犬疾病播散范围更广（P小于0.001）。发生肺转移的犬比未发生肺转移的犬发生脑转移的风险更高（优势比=8.31）。尽管胸部X线摄影准确识别出了12只发生肺转移犬中的10只（83%），但由于病例数量过少，无法评估胸部X线摄影在预测患有恶性肿瘤且有颅内疾病体征的犬是否存在脑转移方面的适用性/准确性。
