Châteauvert J, Pritzker K P, Kessler M J, Grynpas M D
Department of Pathology, Mount Sinai Hospital, University of Toronto, ON, Canada.
J Rheumatol. 1989 Aug;16(8):1098-104.
We analyzed the articular cartilage of 41 rhesus macaques for elemental concentrations including [Ca] calcium, [P] phosphorus, [Mg] magnesium, [S] sulfur, [K] potassium and glycosaminoglycan (GAG) and collagen content. Our findings revealed an increase in all elements with aging. Within the osteoarthritic (OA) groups, young OA had higher levels of all elements than old OA, and significantly greater levels compared to young normals. In addition, GAG content was dramatically increased in young OA. Old OA did not differ from old normals for any elements although GAG levels decreased. Collagen was shown to be stable with increasing age in both normal and OA cartilage, but decreased in OA cartilage. This macaque model of spontaneous OA is valuable because it demonstrates early OA changes typical of experimental models and late changes similar to human OA.
我们分析了41只恒河猴的关节软骨中的元素浓度，包括钙（[Ca]）、磷（[P]）、镁（[Mg]）、硫（[S]）、钾（[K]）以及糖胺聚糖（GAG）和胶原蛋白含量。我们的研究结果显示，所有元素的含量都随年龄增长而增加。在骨关节炎（OA）组中，年轻OA组的所有元素水平均高于老年OA组，且与年轻正常组相比显著更高。此外，年轻OA组的GAG含量显著增加。老年OA组的任何元素含量与老年正常组均无差异，尽管GAG水平有所下降。在正常和OA软骨中，胶原蛋白含量随年龄增长表现稳定，但在OA软骨中有所下降。这种自发性OA猕猴模型很有价值，因为它展示了实验模型典型的早期OA变化以及与人类OA相似的晚期变化。
