Kruse Alexandra Y C, Kvich Lasse, Eickhardt Steffen, Omland Lars H, Bjarnsholt Thomas, Moser Claus
Department of Clinical Microbiology, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark
Department of International Health, Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
J Clin Microbiol. 2015 Jun;53(6):1983-5. doi: 10.1128/JCM.03404-14. Epub 2015 Apr 8.
The protozoan parasite Toxoplasma gondii causes severe opportunistic infections. Here, we report an unexpected diagnosis of cerebral toxoplasmosis. T. gondii was diagnosed by 16S and D2 large-subunit (LSU) ribosomal DNA (rDNA) sequencing of a cerebral biopsy specimen and confirmed by T. gondii-specific PCR and immunohistochemistry. The patient was later diagnosed with HIV/AIDS.
原生动物寄生虫刚地弓形虫可引发严重的机会性感染。在此,我们报告一例出人意料的脑型弓形虫病诊断病例。通过对脑活检标本进行16S和D2大亚基(LSU)核糖体DNA(rDNA)测序诊断出刚地弓形虫,并经刚地弓形虫特异性聚合酶链反应(PCR)和免疫组织化学证实。该患者后来被诊断为感染了人类免疫缺陷病毒/获得性免疫综合征(HIV/AIDS)。