Department of Endocrinology and Metabolism, Affiliated Hospital of Luzhou Medical College, Luzhou 646000, China.
Nutrients. 2015 Apr 3;7(4):2485-98. doi: 10.3390/nu7042485.
Although emerging evidence suggests that low levels of vitamin D may contribute to the development of autoimmune disease, the relationship between vitamin D reduction and autoimmune thyroid disease (AITD), which includes Graves' disease (GD) and Hashimoto thyroiditis (HT), is still controversial. The aim was to evaluate the association between vitamin D levels and AITD through systematic literature review. We identified all studies that assessed the association between vitamin D and AITD from PubMed, Embase, CENTRAL, and China National Knowledge Infrastructure (CNKI) databases. We included studies that compared vitamin D levels between AITD cases and controls as well as those that measured the odds of vitamin D deficiency by AITD status. We combined the standardized mean differences (SMD) or the odds ratios (OR) in a random effects model. Twenty case-control studies provided data for a quantitative meta-analysis. Compared to controls, AITD patients had lower levels of 25(OH)D (SMD: -0.99, 95% CI: -1.31, -0.66) and were more likely to be deficient in 25(OH)D (OR 2.99, 95% CI: 1.88, 4.74). Furthermore, subgroup analyses result showed that GD and HT patients also had lower 25(OH)D levels and were more likely to have a 25(OH)D deficiency, suggesting that low levels of serum 25(OH)D was related to AITD.
虽然新出现的证据表明维生素 D 水平低可能导致自身免疫性疾病的发生，但维生素 D 降低与自身免疫性甲状腺疾病（AITD）之间的关系仍存在争议，AITD 包括格雷夫斯病（GD）和桥本甲状腺炎（HT）。目的是通过系统文献回顾评估维生素 D 水平与 AITD 之间的关联。我们从 PubMed、Embase、CENTRAL 和中国国家知识基础设施（CNKI）数据库中确定了所有评估维生素 D 与 AITD 之间关联的研究。我们纳入了比较 AITD 病例和对照组之间维生素 D 水平以及测量 AITD 状态下维生素 D 缺乏几率的研究。我们采用随机效应模型合并标准化均数差（SMD）或比值比（OR）。20 项病例对照研究提供了定量荟萃分析的数据。与对照组相比，AITD 患者的 25（OH）D 水平较低（SMD：-0.99，95%CI：-1.31，-0.66），更有可能缺乏 25（OH）D（OR 2.99，95%CI：1.88，4.74）。此外，亚组分析结果表明，GD 和 HT 患者的 25（OH）D 水平也较低，且更有可能出现 25（OH）D 缺乏，这表明血清 25（OH）D 水平低与 AITD 有关。
