Pamuk Gülsüm Emel, Top Mehmet Şerif, Uyanık Mehmet Şevki, Köker Hilal, Akker Mustafa, Ak Recep, Yürekli Ömer Atalay, Çelik Yahya
Department of Hematology, Trakya University Medical Faculty, Eski Yildiz Cad. Park Apt. No:22 Daire:18, Beşiktaş, Istanbul/Edirne, Turkey.
Department of Psychiatry, Edirne State Hospital, Edirne, Turkey.
Wien Klin Wochenschr. 2016 Dec;128(Suppl 8):576-580. doi: 10.1007/s00508-015-0740-8. Epub 2015 Apr 9.
In this study, we determined the frequency of migraine headache in iron-deficiency anemia (IDA) patients and whether it was related to anxiety, depression, and somatization.
We included 127 consecutive IDA patients into the study. All patients were asked validated questions about headache and migraine face-to-face. They were administered validated questionnaires for anxiety-depression The Hospital Anxiety and Depression Scale and somatization. The quality of life (QoL) disturbance associated with headache was marked on a 0-10 VAS.
Of all IDA patients, 79.5 % defined headache at any time of their life. In addition, 36.2 % of all IDA patients defined the criteria for migraine. IDA patients with migraine were more frequently smokers and had significantly lower hemoglobin and mean corpuscular volume values (p values < 0.05). The IDA group with migraine had significantly higher mean anxiety score (p = 0.046) and headache-related QoL disturbance score (p = 0.021) than the IDA group without migraine. Migraine patients with aura had lower hemoglobin values (p = 0.02), higher depression scores (p = 0.005), and higher migraine-related QoL disturbance scores than others.
IDA patients have a high frequency of migraine headache. The presence of anxiety and depression have great influence on the presence of migraine in IDA patients.
在本研究中，我们确定了缺铁性贫血（IDA）患者偏头痛的发生率，以及它是否与焦虑、抑郁和躯体化有关。
我们纳入了127例连续的IDA患者进行研究。所有患者均被面对面询问关于头痛和偏头痛的有效问题。他们接受了用于焦虑抑郁的有效问卷——医院焦虑抑郁量表以及躯体化问卷。与头痛相关的生活质量（QoL）障碍在0-10视觉模拟量表（VAS）上进行评分。
在所有IDA患者中，79.5%的患者在其一生中的任何时候都有头痛症状。此外，所有IDA患者中有36.2%符合偏头痛的标准。患有偏头痛的IDA患者吸烟更为频繁，血红蛋白和平均红细胞体积值显著更低（p值<0.05）。与无偏头痛的IDA组相比，有偏头痛的IDA组平均焦虑评分（p = 0.046）和与头痛相关的QoL障碍评分显著更高（p = 0.021）。有先兆的偏头痛患者血红蛋白值更低（p = 0.02），抑郁评分更高（p = 0.005），且与偏头痛相关的QoL障碍评分高于其他患者。
IDA患者偏头痛的发生率很高。焦虑和抑郁的存在对IDA患者偏头痛的发生有很大影响。
