Department of Neurology, Faculty of Medicine, Balikesir University, Balıkesir, Turkey.
Eur Rev Med Pharmacol Sci. 2024 Feb;28(3):995-1001. doi: 10.26355/eurrev_202402_35335.
Migraine is an episodic public health problem that usually occurs with a severe headache. Various mechanisms and outcomes have been reported between iron deficiency anemia (IDA) and migraine. We aimed to investigate the effect of the presence and severity of anemia and iron parameters on the frequency and severity of migraine attacks.
The study included 104 patients with IDA and newly diagnosed migraine in the neurology outpatient clinic and 38 age and gender-matched controls with normal hemoglobin levels. Patients were divided into 3 subgroups (mild, moderate, and severe anemia) to determine a significant relationship between the severity of IDA and migraine attacks. All patients were asked validated questions with the Visual Analogue Scale (VAS), Headache Impact Test-6 (HIT-6), and the Hamilton Anxiety Rating Scale (HAM-A) face-to-face.
In this study, 85.6% of the participants were female, and 22 (14.6%) of them were male. Thirty-two mild anemia patients' mean age was 36.6 ± 12.5, 41 with moderate anemia was 46 ± 14.2, and 31 with severe anemia patients' mean age was 48 ± 14.1. There was no significant difference between the subgroups in VAS, HIT-6 score, headache type, and headache frequency. Menstrual migraine is associated with low hemoglobin levels. A significant increase was found in VAS and HIT-6 scores with low ferritin levels.
The presence and severity of anemia and iron deficiency do not affect the frequency and severity of migraine attacks in groups other than menstruation-related migraine. An inverse relationship was found between VAS, HIT-6, and ferritin levels. VAS was found to be more effective than HIT-6.
偏头痛是一种间歇性的公共卫生问题，通常伴有严重头痛。缺铁性贫血（IDA）和偏头痛之间已经报道了各种机制和结果。我们旨在研究贫血的存在和严重程度以及铁参数对偏头痛发作频率和严重程度的影响。
该研究包括在神经内科门诊就诊的 104 例 IDA 和新诊断的偏头痛患者和 38 名年龄和性别匹配的血红蛋白水平正常的对照组。患者分为 3 个亚组（轻度、中度和重度贫血），以确定 IDA 的严重程度与偏头痛发作之间的显著关系。所有患者均面对面使用视觉模拟量表（VAS）、头痛影响测试-6（HIT-6）和汉密尔顿焦虑量表（HAM-A）进行验证性问题的询问。
在这项研究中，85.6%的参与者为女性，22 名（14.6%）为男性。32 名轻度贫血患者的平均年龄为 36.6 ± 12.5 岁，41 名中度贫血患者为 46 ± 14.2 岁，31 名重度贫血患者的平均年龄为 48 ± 14.1 岁。在 VAS、HIT-6 评分、头痛类型和头痛频率方面，亚组之间无显著差异。月经性偏头痛与低血红蛋白水平有关。低铁蛋白水平时 VAS 和 HIT-6 评分显著升高。
除与月经有关的偏头痛外，贫血的存在和严重程度以及缺铁不会影响偏头痛发作的频率和严重程度。VAS、HIT-6 和铁蛋白水平之间呈负相关。VAS 比 HIT-6 更有效。
