Fan Xiangyu, Abd Alla Abu Algasim Elgaili, Xie Jianping
a State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, Key Laboratory of Ministry of Education Eco-Environment of the Three Gorges Reservoir Region, Institute of Modern Biopharmaceuticals, School of Life Sciences , Southwest University , Beibei, Chongqing 400700 , China.
b School of Biological Science and Technology , University of Jinan , Shandong 250022 , China.
J Biomol Struct Dyn. 2016;34(2):233-8. doi: 10.1080/07391102.2015.1022602. Epub 2015 Apr 9.
Mycobacterium tuberculosis complex (MTBC) is notorious for causing diseases, such as tuberculosis. Tuberculosis caused by M. tuberculosis remains a global public health concern. Two prophages, phiRv1 and phiRv2, can be found among most MTBC genomes. However, no precise functions have been assigned for the two prophages. In this paper, to find out the function of these two prophages, the distribution and function of phiRv1 and phiRv2 in MTBC genomes were analyzed from multiple omics data. We found that complex insertion, deletion, and reorganization appeared on the locus of two prophages in MTBC genomes; some genes of the two prophages can be translated and are functional from proteomic data; the expression of other prophage genes, such as Rv1577c, Rv2650c, Rv2652c, Rv2659c, and Rv2658c, can vary with environmental stresses and might enhance the fitness of MTBC. These data will facilitate our in-depth understanding of their function.
结核分枝杆菌复合群（MTBC）因引发疾病（如结核病）而声名狼藉。由结核分枝杆菌引起的结核病仍是全球公共卫生关注的问题。在大多数MTBC基因组中可以发现两种前噬菌体，即phiRv1和phiRv2。然而，尚未明确这两种前噬菌体的具体功能。本文为了探究这两种前噬菌体的功能，从多个组学数据对MTBC基因组中phiRv1和phiRv2的分布及功能进行了分析。我们发现MTBC基因组中两种前噬菌体的位点出现了复杂的插入、缺失和重组；从蛋白质组学数据可知，这两种前噬菌体的一些基因能够翻译且具有功能；其他前噬菌体基因（如Rv1577c、Rv2650c、Rv2652c、Rv2659c和Rv2658c）的表达会随环境压力而变化，可能会增强MTBC的适应性。这些数据将有助于我们深入了解它们的功能。
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