Chellini Elisabetta, Fondelli Maria Cristina, Maurello Maria Teresa, Sciarra Gianfranco, Aprea Maria Cristina, Carreras Giulia
SC epidemiologia ambientaleoccupazionale, Istituto per lo studio e la prevenzione oncologica (ISPO), Firenze.
Epidemiol Prev. 2015 Jan-Feb;39(1):28-35.
to identify the biomarkers to use in order to evaluate the level and trend of exposure to environmental pollutants from a plant which retrieves and refines precious metals and burns toxic waste.
human biomonitoring cross sectional study on a small sample of population resident in the study area.
blood and urinary samples, and questionnaires from volunteers resident at least for 10 years in Civitella in Val di Chiana area (Arezzo Province, Tuscany Region, Central Italy), where the plant is located, and in a control area; they had to be 5-year non-smokers or ex-smokers, in good health status and non occupationally exposed to heavy metals and/or combustion products.
geometric mean and 95th percentile (P95) of mercury (Hg) and cadmium (Cd) blood concentrations, and of the urinary concentrations of antimony (Sb), silver (Ag), arsenic (As), Cd, cobalt (Co), chromium (Cr), Hg, nickel (Ni), platinum (Pt), 1-hydroxypyrene, and trans, trans-muconic acid in the two populations; quantity and pattern of porphyrins in the 24-hour urines of Civitella volunteers. Student's "t" test calculated on the means of data with logarithmic transformation was used to compare the two groups. In case of significant differences linear regression analyses have been performed using questionnaire information. The distribution of observed data was compared with specific reference values.
Sb, Cd, and Ni concentrations were significantly higher in Civitella population (39 subjects), while Cr concentration was higher in the control group (18 subjects). No correlations with the individual characteristics have been observed. The 30.3%of subjects who gave their 24- hour urine had a distorted pattern of porphyrins.
the results confirmed the need to perform human biomonitoring in the Civitella area, increasing the number of samples, using urine as biological matrix, and monitoring at least Sb, Cd, Ni, Pt, Ag, and porphyrins.
确定用于评估一家回收和精炼贵金属并焚烧有毒废物的工厂所产生的环境污染物暴露水平及趋势的生物标志物。
对研究区域内一小部分居民进行的人体生物监测横断面研究。
采集位于奇维泰拉因瓦尔迪基亚纳地区（意大利中部托斯卡纳大区阿雷佐省）该工厂所在地以及一个对照区域的至少居住10年的志愿者的血液和尿液样本，并收集问卷；他们必须是已戒烟5年或曾经吸烟的人，健康状况良好，且未在职业上接触重金属和/或燃烧产物。
两组人群中汞（Hg）和镉（Cd）的血液浓度、锑（Sb）、银（Ag）、砷（As）、镉（Cd）、钴（Co）、铬（Cr）、汞（Hg）、镍（Ni）、铂（Pt）、1 - 羟基芘以及反式，反式 - 粘康酸的尿液浓度的几何均值和第95百分位数（P95）；奇维泰拉志愿者24小时尿液中卟啉的含量及模式。对经对数转换后的数据均值进行学生“t”检验以比较两组。若存在显著差异，则使用问卷信息进行线性回归分析。将观察到的数据分布与特定参考值进行比较。
奇维泰拉人群（39名受试者）中Sb、Cd和Ni的浓度显著更高，而对照组（18名受试者）中Cr的浓度更高。未观察到与个体特征的相关性。提供24小时尿液的受试者中有30.3%的人卟啉模式异常。
结果证实有必要在奇维泰拉地区进行人体生物监测，增加样本数量，将尿液用作生物基质，并至少监测Sb、Cd、Ni、Pt、Ag和卟啉。
