甲型流感病毒感染研究：追踪感染及限制嗜性的工具
Investigating influenza A virus infection: tools to track infection and limit tropism.
作者信息
Fiege Jessica K, Langlois Ryan A
机构信息
Department of Microbiology and Immunology and Center for Immunology, University of Minnesota, Minneapolis, Minnesota, USA.
Department of Microbiology and Immunology and Center for Immunology, University of Minnesota, Minneapolis, Minnesota, USA
出版信息
J Virol. 2015 Jun;89(12):6167-70. doi: 10.1128/JVI.00462-15. Epub 2015 Apr 8.
Abstract
Influenza A viruses display a broad cellular tropism within the respiratory tracts of mammalian hosts. Uncovering the relationship between tropism and virus immunity, pathogenesis, and transmission will be critical for the development of therapeutic interventions. Here we discuss recent developments of several recombinant strains of influenza A virus. These viruses have inserted reporters to track tropism, microRNA target sites to restrict tropism, or barcodes to assess transmission dynamics, expanding our understanding of pathogen-host interactions.
摘要
甲型流感病毒在哺乳动物宿主的呼吸道内表现出广泛的细胞嗜性。揭示嗜性与病毒免疫、发病机制及传播之间的关系对于治疗干预措施的开发至关重要。在此，我们讨论甲型流感病毒几种重组毒株的最新进展。这些病毒插入了用于追踪嗜性的报告基因、用于限制嗜性的微小RNA靶位点或用于评估传播动态的条形码，从而拓展了我们对病原体与宿主相互作用的理解。
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