Serhan Charles N, Chiang Nan, Dalli Jesmond
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Harvard Institutes of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, United States.
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Harvard Institutes of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, United States.
Semin Immunol. 2015 May;27(3):200-15. doi: 10.1016/j.smim.2015.03.004. Epub 2015 Apr 7.
Studies into the mechanisms in resolution of self-limited inflammation and acute reperfusion injury have uncovered a new genus of pro-resolving lipid mediators coined specialized pro-resolving mediators (SPM) including lipoxins, resolvins, protectins and maresins that are each temporally produced by resolving-exudates with distinct actions for return to homeostasis. SPM evoke potent anti-inflammatory and novel pro-resolving mechanisms as well as enhance microbial clearance. While born in inflammation-resolution, SPM are conserved structures with functions discovered in microbial defense, pain, organ protection and tissue regeneration, wound healing, cancer, reproduction, and neurobiology-cognition. This review covers these SPM mechanisms and other new omega-3 PUFA pathways that open their path for functions in resolution physiology.
对自限性炎症和急性再灌注损伤消退机制的研究发现了一类新的促消退脂质介质，称为特殊促消退介质（SPM），包括脂氧素、消退素、保护素和maresin，它们分别由消退渗出物在不同时间产生，具有不同作用以恢复内环境稳态。SPM引发强大的抗炎和新型促消退机制，并增强微生物清除。虽然SPM产生于炎症消退过程中，但它们是保守结构，在微生物防御、疼痛、器官保护和组织再生、伤口愈合、癌症、生殖以及神经生物学 - 认知等方面具有已发现的功能。本综述涵盖了这些SPM机制以及其他新的ω-3多不饱和脂肪酸途径，这些途径为其在消退生理学中的功能开辟了道路。
