Mawar N, Katendra T, Bagul R, Bembalkar S, Vedamurthachar A, Tripathy S, Srinivas K, Mandar K, Kumar N, Gupte N, Paranjape R S
National AIDS Research Institute (ICMR), Pune, India.
Indian J Med Res. 2015 Jan;141(1):90-9. doi: 10.4103/0971-5916.154509.
BACKGROUND & OBJECTIVES: Improving quality of life (QOL) of healthy people living with HIV (PLHIV) is critical needing home-based, long-term strategy. Sudarshan Kriya yoga (SKY) intervention is acknowledged for its positive impact on health. It is hypothesised that SKY would improve PLHIV's QOL, justifying an evaluation.
In this open label randomized controlled pilot trial, 61 adult PLHIV with CD4 count more than 400 cells/µl and Karnofsky scale score above 70 were enrolled. Those with cardiac disease, jaundice, tuberculosis, or on antiretroviral therapy/yoga intervention were excluded. All were given standard care, randomized to SKY intervention (31: I-SKY) and only standard of care in control (30: O-SOC) arms. The I-SKY participants were trained for six days to prepare for daily practice of SKY at home for 30 min. A validated 31-item WHOQOL-HIVBREF questionnaire was used to document effect in both arms from baseline to three visits at 4 wk interval.
Baseline QOL scores, hypertension and CD4 count were similar in both arms. An overall 6 per cent improvement of QOL scores was observed in I-SKY group as compared to O-SOC group, after controlling for baseline variables like age, gender, education and occupation ( p =0.016); 12 per cent for physical ( p =0.004), 11 per cent psychological (p =0.023) and 9 per cent level of independence (p =0.001) domains. Improvement in I-SKY observed at post-training and in the SKY adherence group showed increase in these two domains.
A significant improvement in QOL scores was observed for the three health related QOL domains in SKY intervention arm. This low cost strategy improved physical and psychological state of PLHIV calling for upscaling with effective monitoring for sustainability of quality of life.
提高健康的艾滋病毒感染者(PLHIV)的生活质量(QOL)至关重要,这需要基于家庭的长期策略。苏达山克里亚瑜伽(SKY)干预因其对健康的积极影响而得到认可。据推测,SKY将改善PLHIV的生活质量,因此有必要进行一项评估。
在这项开放标签随机对照试验中,纳入了61名CD4细胞计数超过400个/微升且卡诺夫斯基量表评分高于70的成年PLHIV。排除患有心脏病、黄疸、结核病或正在接受抗逆转录病毒治疗/瑜伽干预的患者。所有患者均接受标准护理,随机分为SKY干预组(31例:I-SKY)和仅接受标准护理的对照组(30例:O-SOC)。I-SKY组的参与者接受了为期6天的培训,为在家中每天练习30分钟的SKY做准备。使用经过验证的31项WHOQOL-HIVBREF问卷记录两组从基线到每隔4周进行的三次访视期间的效果。
两组的基线生活质量评分、高血压和CD4细胞计数相似。在控制年龄、性别、教育程度和职业等基线变量后,I-SKY组的生活质量评分总体提高了6%,与O-SOC组相比(p = 0.016);身体领域提高了12%(p = 0.004),心理领域提高了11%(p = 0.023),独立水平领域提高了9%(p = 0.001)。在训练后和SKY依从组中观察到的I-SKY组的改善在这两个领域有所增加。
在SKY干预组中,与健康相关的三个生活质量领域的评分有显著改善。这种低成本策略改善了PLHIV的身体和心理状态,需要扩大规模并进行有效监测以确保生活质量的可持续性。