Department of Medicine, Washington University School of Medicine, 4940 Parkview Place, St Louis, MO 63110, USA.
HIV Med. 2010 Jul 1;11(6):379-88. doi: 10.1111/j.1468-1293.2009.00801.x. Epub 2010 Jan 5.
People living with HIV infection are at increased risk for developing cardiovascular disease (CVD). Safe and effective interventions for lowering CVD risk in HIV infection are high priorities. We conducted a prospective, randomized, controlled study to evaluate whether a yoga lifestyle intervention improves CVD risk factors, virological or immunological status, or quality of life (QOL) in HIV-infected adults relative to standard of care treatment in a matched control group.
Sixty HIV-infected adults with mild-moderate CVD risk were assigned to 20 weeks of supervised yoga practice or standard of care treatment. Baseline and week 20 measures were: 2-h oral glucose tolerance test with insulin monitoring, body composition, fasting serum lipid/lipoprotein profile, resting blood pressures, CD4 T-cell count and plasma HIV RNA, and the Medical Outcomes Study Short Form (SF)-36 health-related QOL inventory.
Resting systolic and diastolic blood pressures improved more (P=0.04) in the yoga group (-5 +/- 2 and -3 +/- 1 mmHg, respectively) than in the standard of care group (+1 +/- 2 and+2 +/- 2 mmHg, respectively). However, there was no greater reduction in body weight, fat mass or proatherogenic lipids, or improvements in glucose tolerance or overall QOL after yoga. Immune and virological status was not adversely affected.
Among traditional lifestyle modifications, yoga is a low-cost, simple to administer, nonpharmacological, popular behavioural intervention that can lower blood pressure in pre-hypertensive HIV-infected adults with mild-moderate CVD risk factors.
感染 HIV 的人罹患心血管疾病（CVD）的风险增加。降低 HIV 感染者 CVD 风险的安全有效干预措施是当务之急。我们进行了一项前瞻性、随机、对照研究，以评估瑜伽生活方式干预是否能改善 HIV 感染成年人的 CVD 风险因素、病毒学或免疫学状态或生活质量（QOL），与匹配对照组的标准治疗相比。
60 名 CVD 风险处于轻度至中度的 HIV 感染者被分配到 20 周的监督瑜伽练习或标准治疗。基线和第 20 周的测量指标包括：口服 2 小时葡萄糖耐量试验并监测胰岛素、身体成分、空腹血清脂质/脂蛋白谱、静息血压、CD4 T 细胞计数和血浆 HIV RNA，以及医疗结果研究简表（SF）-36 健康相关 QOL 量表。
瑜伽组的静息收缩压和舒张压改善更明显（P=0.04）（分别为-5 +/- 2 和-3 +/- 1 mmHg），而标准治疗组分别为+1 +/- 2 和+2 +/- 2 mmHg）。然而，瑜伽后体重、体脂或致动脉粥样硬化脂质的减少没有更大，葡萄糖耐量或整体 QOL 也没有改善。免疫和病毒学状态没有受到不利影响。
在传统的生活方式改变中，瑜伽是一种低成本、易于管理、非药物的流行行为干预措施，可降低轻度至中度 CVD 危险因素的 HIV 感染、高血压前期成年人的血压。
