†Center for Degradable and Flame-Retardant Polymeric Materials (ERCEPM-MoE), National Engineering Laboratory of Eco-Friendly Polymeric Materials (Sichuan), State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, Sichuan 610064, China.
‡School of Energy Science and Engineering, University of Electronic Science and Technology of China, Chengdu, Sichuan 611731, China.
ACS Nano. 2015;9(4):4649-59. doi: 10.1021/acsnano.5b01370. Epub 2015 Apr 13.
It is extremely important for emerging applications and still enormously challenging to develop multifunctional stimuli-responsive anisotropic polymeric micelles with integration of potentially targeted therapeutic and diagnostic function. Herein, we report a first example of fluorescent anisotropic micelles (FAMs) with Fe(3+), DTT, H2O2, and thermal responsive fluorescence and morphology. FAMs from direct aqueous self-assembly of amphiphilic diblock copolymer showed reversible "switch off/on" of aqua fluorescent emission and controllable structural change by sequential addition of Fe(3+) and DTT. In addition, the FAMs had reversible dual-thermal responsiveness of fluorescence and morphology. This micelle could serve as a promising candidate for all-in-one application of quantitative detecting, imaging, drug delivery, and targeted release.
对于新兴应用来说，开发多功能刺激响应各向异性聚合物胶束具有潜在靶向治疗和诊断功能非常重要。本文报道了首例具有 Fe(3+)、DTT、H2O2 和热响应荧光和形态的各向异性荧光胶束（FAMs）。两亲性嵌段共聚物在直接水相中自组装形成 FAMs，通过顺序添加 Fe(3+)和 DTT 可实现水相荧光发射的可逆“关/开”。此外，FAMs 具有荧光和形态的可逆双重热响应性。该胶束有望成为定量检测、成像、药物传递和靶向释放的一体化应用的有前途的候选物。
