Zhao Lingzhou, Shi Xiangyang, Zhao Jinhua
Department of Nuclear Medicine, Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University, 100 Haining Road, Shanghai 200080, People's Republic of China.
Curr Top Med Chem. 2015;15(13):1196-208. doi: 10.2174/1568026615666150330110822.
This review reports the recent advances in chlorotoxin (CTX)-targeted nanoparticles (NPs) for imaging and therapy of glioma. CTX has been identified as a targeting ligand to specifically bind to glioma. Through different conjugation approaches, CTX can be conjugated onto iron oxide NPs, quantum dots, and rare-earth upconversion NPs for targeted magnetic resonance and fluorescence imaging of glioma. Likewise, CTX-conjugated NPs can also be used as a carrier system to load anticancer drugs or therapeutic genes for targeted chemotherapy or gene therapy of glioma, respectively. Some of the key developments in this area of research will be introduced in detail. Challenges and future perspectives in the development of CTX-conjugated NPs will be discussed.
本综述报告了用于神经胶质瘤成像和治疗的氯毒素（CTX）靶向纳米颗粒（NPs）的最新进展。CTX已被确定为一种靶向配体，可特异性结合神经胶质瘤。通过不同的偶联方法，CTX可以偶联到氧化铁纳米颗粒、量子点和稀土上转换纳米颗粒上，用于神经胶质瘤的靶向磁共振和荧光成像。同样，CTX偶联的纳米颗粒也可以用作载体系统，分别装载抗癌药物或治疗基因，用于神经胶质瘤的靶向化疗或基因治疗。将详细介绍该研究领域的一些关键进展。还将讨论CTX偶联纳米颗粒开发中的挑战和未来前景。
