College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, People's Republic of China.
Holistic Integrative Pharmacy Institutes, Hangzhou Normal University, Hangzhou, Zhejiang, People's Republic of China.
Int J Nanomedicine. 2020 Apr 17;15:2563-2582. doi: 10.2147/IJN.S243223. eCollection 2020.
Gliomas are the most common tumor of the central nervous system. However, the presence of the brain barrier blocks the effective delivery of drugs and leads to the treatment failure of various drugs. The development of a nanoparticle drug delivery system (NDDS) can solve this problem. In this review, we summarized the brain barrier (including blood-brain barrier (BBB), blood-brain tumor barriers (BBTB), brain-cerebrospinal fluid barrier (BCB), and nose-to-brain barrier), NDDS of glioma (such as passive targeting systems, active targeting systems, and environmental responsive targeting systems), and NDDS efficacy improvement strategies and deficiencies. The research prospect of drug-targeted delivery systems for glioma is also discussed.
神经胶质瘤是中枢神经系统最常见的肿瘤。然而，脑屏障的存在阻碍了药物的有效传递，导致各种药物的治疗失败。纳米颗粒药物递送系统（NDDS）的发展可以解决这个问题。在这篇综述中，我们总结了脑屏障（包括血脑屏障（BBB）、血脑肿瘤屏障（BBTB）、脑脑脊液屏障（BCB）和鼻脑屏障）、神经胶质瘤的 NDDS（如被动靶向系统、主动靶向系统和环境响应靶向系统）以及 NDDS 功效改善策略和缺陷。还讨论了神经胶质瘤靶向药物递送系统的研究前景。
