Nagata M, Kawaguchi H, Komatsu Y, Hattori M, Itoh K
Nihon Jinzo Gakkai Shi. 1989 Jul;31(7):713-21.
Sairei-tô, one of the herb drugs, has been demonstrated to have several effects. Clinically, evidence have been accumulated showing that sairei-tô has been able to reduce the frequency of relapse in minimal change nephrotic syndrome. It has also found that sairei-to has improved proteinurial in minimal change nephrotic syndrome as well as chronic glomerulonephritis in man. Although the mechanism of such effects is still unclear, it is supposed that its immune modulating actions that has been reported. In this study, we quantitated the number of intrarenal Ia positive cells and T cells in nephrotoxic nephritis in rats in order to clarify the intrarenal immune actions of sairei-tô on immune mediated glomerulonephritis. Four groups of rats with nephrotoxic nephritis were experimented on. The first group was the controlled group, had no treatment whatsoever. The second group was administered with MPSL (solu-medrol 20 mg/kg, alternate day). The fourth group with both sairei-tô and MPSL. The level of proteinuria in three groups treated was almost the same, that is, less than that of controlled group. On light microscopy, sairei-tô suppressed glomerular inflammation such as endocapillary proliferative lesions and mesangial expansion, which were shown in controlled group. The histological improvement was almost the found in rats treated with MPSL and both. Sairei-tô suppressed infiltrations of intraglomerular Ia positive cells (P less than 0.01) and T cells (P less than 0.01) on the 7th day and 14th day as well. Remarkable suppression of T cells infiltration was noted in rats treated with MPSL along with sairei-to on the 14th day (P less than 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)
柴苓汤是草药药物之一，已被证明有多种作用。临床上，已有证据表明柴苓汤能够降低微小病变肾病综合征的复发频率。还发现柴苓汤可改善微小病变肾病综合征以及人类慢性肾小球肾炎的蛋白尿情况。尽管这种作用机制仍不清楚，但推测与其已报道的免疫调节作用有关。在本研究中，为阐明柴苓汤对免疫介导性肾小球肾炎的肾内免疫作用，我们对大鼠肾毒性肾炎肾内Ia阳性细胞和T细胞数量进行了定量分析。对四组肾毒性肾炎大鼠进行了实验。第一组为对照组，未接受任何治疗。第二组给予甲泼尼龙琥珀酸钠（甲强龙20mg/kg，隔日一次）。第四组给予柴苓汤和甲泼尼龙琥珀酸钠。接受治疗的三组蛋白尿水平几乎相同，即低于对照组。光镜下，柴苓汤抑制了如对照组所见的毛细血管内增生性病变和系膜扩张等肾小球炎症。用甲泼尼龙琥珀酸钠治疗的大鼠以及两者联合治疗的大鼠组织学改善情况基本相同。柴苓汤在第7天和第14天也抑制了肾小球内Ia阳性细胞浸润（P<0.01）和T细胞浸润（P<0.01）。在第14天，用甲泼尼龙琥珀酸钠联合柴苓汤治疗的大鼠T细胞浸润明显受到抑制（P<0.01）。（摘要截选至250字）
