烯烃向全氟氧化吲哚的无金属串联环化反应。
Metal-free cascade cyclization of alkenes toward perfluorinated oxindoles.
作者信息
Tang Shi, Li Zhi-Hao, Wang Ming-Wei, Li Zhi-Ping, Sheng Rui-Long
机构信息
College of Chemistry and Chemical Engineering, Jishou University, Jishou 416000, China.
出版信息
Org Biomol Chem. 2015 May 14;13(18):5285-8. doi: 10.1039/c5ob00454c.
PMID:25858623
Abstract
A simple AIBN-mediated cyclization reaction of activated alkenes toward perfluorinated oxindoles is developed. In the presence of readily available AIBN, N-arylacrylamide and perfluoroalkyl iodides underwent perfluorination reaction to give perfluorinated oxindoles in good to excellent yields under metal-free conditions.
摘要
开发了一种简单的由偶氮二异丁腈介导的活性烯烃向全氟氧化吲哚的环化反应。在易于获得的偶氮二异丁腈存在下，N-芳基丙烯酰胺和全氟烷基碘化物发生全氟化反应，在无金属条件下以良好至优异的产率得到全氟氧化吲哚。
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