Department of Clinical Neuroscience/Psychiatry, Karolinska Institutet, Karolinska University Hospital, Solna SE-171 76 Stockholm, Sweden.
Department of Children's and Women's Health, Center for Neurodevelopmental Disorders at Karolinska Institutet (KIND), Gävlegatan 22B, 113 30 Stockholm, Sweden.
Psychiatry Res. 2015 Jun 30;227(2-3):253-7. doi: 10.1016/j.psychres.2015.03.025. Epub 2015 Mar 31.
Elevated T3 levels have been reported in men with antisocial behavior. The aim of the present study was to investigate the relationship between thyroid hormones and expressed adult interpersonal violence in female patients with borderline personality disorder (BPD). Furthermore, expressed adult interpersonal violence in female BPD patients was compared to healthy female controls. A total of 92 clinically euthyroid women with BPD and 57 healthy women were assessed with the Karolinska Interpersonal Violence Scales (KIVS). Baseline thyroid function was evaluated by measuring plasma free and bound triiodothyronine (FT3 and T3), thyroxine (FT4 and T4), and thyroid-stimulating hormone (TSH) with immunoassays in patients. Plasma cortisol was also measured. Among females with BPD, expressed interpersonal violence as an adult showed a significant positive correlation with the T3 levels. The mean expression of interpersonal violence as an adult was significantly higher in BPD patients as compared to healthy controls. The multiple regression model indicated that two independent predictors of KIVS expressed interpersonal violence as an adult: T3 and comorbid diagnosis of alcohol abuse. Association between T3 levels and violent/aggressive behavior earlier reported exclusively in male samples may be valid also in females with BPD.
已有研究报道，反社会行为男性的 T3 水平升高。本研究旨在探讨甲状腺激素与边缘型人格障碍（BPD）女性患者成年表达人际暴力之间的关系。此外，还将 BPD 女性患者的成年表达人际暴力与健康女性对照组进行了比较。使用 Karolinska 人际暴力量表（KIVS）对 92 名临床甲状腺功能正常的 BPD 女性患者和 57 名健康女性进行了评估。通过免疫分析法测量游离和结合三碘甲状腺原氨酸（FT3 和 T3）、甲状腺素（FT4 和 T4）和促甲状腺激素（TSH），评估患者的基础甲状腺功能。还测量了血浆皮质醇。在 BPD 女性中，成年表达的人际暴力与 T3 水平呈显著正相关。与健康对照组相比，BPD 患者成年表达的人际暴力明显更高。多元回归模型表明，KIVS 成年表达人际暴力的两个独立预测因子为 T3 和酒精滥用共病诊断。仅在男性样本中报告的 T3 水平与暴力/攻击行为之间的关联，可能在 BPD 女性中也是有效的。
