Kaya Şüheda, Özsoy Filiz, Taşcı Gülay, Kalaycı Mehmet
Elazığ Mental Health and Diseases Hospital, Elazığ, Turkey.
Department of Psychiatry, Tokat State Hospital, Tokat, Turkey.
Psychiatry Investig. 2020 Sep;17(9):889-895. doi: 10.30773/pi.2020.0067. Epub 2020 Sep 9.
This study aims to investigate the levels of nesfatin-1-hormone in patients with Antisocial Personality Disorder (ASPD) and their relationship with clinical variables.
A total of 90 people (45 ASPD, 45 controls) were included in our study. Sociodemographic Data Form, Beck-Depression-Inventory (BDI), Beck-Anxiety-Inventory (BAI), Barratt Impulsivity Scale (BIS-11), Buss-Durkee-Hostility-Inventory (BDHI) were applied to all participants. Venous blood samples were taken from participants at the same time of the day when they were hungry.
It was found that the BDI and BAI scores of the ASPD were higher than those of the controls (p<0.001, for both scales). The scores in BIS-11; motor and nonplanning-impulsivity subscales were higher than those of the controls (p<0.001, 0.036, respectively). The scores obtained by the ASPD were higher in all subscales of BDHI (p<0.001). For the nesfatin-1-hormone, the values of the ASPD were lower than those of the controls (p=0.044). No relationship was found between the nesfatin-1-hormone and any other laboratory parameters and applied scales (p>0.05).
This is the first study to examine the nesfatin-1-hormone levels in patients with any personality disorder. Further studies with more participants are needed in different types of personality disorders to understand the relationship between personality disorder and nesfatin-1-hormone levels.
本研究旨在调查反社会型人格障碍（ASPD）患者体内的促食欲素-1（nesfatin-1）激素水平及其与临床变量的关系。
本研究共纳入90人（45例ASPD患者，45例对照）。所有参与者均填写社会人口学数据表、贝克抑郁量表（BDI）、贝克焦虑量表（BAI）、巴拉特冲动量表（BIS-11）、布斯-杜克敌意量表（BDHI）。在参与者饥饿的同一天同一时间采集静脉血样。
发现ASPD患者的BDI和BAI评分高于对照组（两个量表均p<0.001）。BIS-11的运动冲动和非计划性冲动分量表得分高于对照组（分别为p<0.001和0.036）。ASPD患者在BDHI所有分量表上的得分均较高（p<0.001）。促食欲素-1激素方面，ASPD患者的值低于对照组（p=0.044）。未发现促食欲素-1激素与任何其他实验室参数及所应用量表之间存在关联（p>0.05）。
这是第一项研究任何人格障碍患者促食欲素-1激素水平的研究。需要在不同类型的人格障碍中纳入更多参与者进行进一步研究，以了解人格障碍与促食欲素-1激素水平之间的关系。
