Icli Atilla, Aksoy Fatih, Nar Gökay, Kaymaz Haci, Alpay Mehmet Fatih, Nar Rukiye, Guclu Aydın, Arslan Akif, Dogan Abdullah
Department of Cardiology, Ahi Evran University, Kirsehir, Turkey
Department of Cardiology, Suleyman Demirel University, Isparta, Turkey.
Angiology. 2016 Feb;67(2):146-50. doi: 10.1177/0003319715579781. Epub 2015 Apr 9.
Familial hypercholesterolemia (FH) is a genetic disorder of lipoprotein metabolism and increases the risk of premature cardiovascular diseases. In patients with FH, platelet function may be activated; however, the extent of this activation and its etiology are unclear. We aimed to evaluate the mean platelet volume (MPV), a marker of platelet activation, in patients with FH. The study group consisted of 164 patients with FH and 160 control patients. Controls were matched for age, gender, hypertension, and smoking. The MPV was significantly higher in patients with FH than in controls (9.2 ± 0.4 vs 7.9 ± 0.6 fL, respectively; P < .001). Platelet count was significantly lower among patients with FH when compared to control patients (259 ± 51 vs 272 ± 56 × 10(3)/L, respectively; P = .03). In linear regression analysis, MPV was independently associated only with total cholesterol (β = .6, 95% confidence interval: 0.004-0.008, P < .001). We have shown that MPV was increased in patients with FH and that it was independently associated with total cholesterol level.
家族性高胆固醇血症（FH）是一种脂蛋白代谢的遗传性疾病，会增加早发性心血管疾病的风险。在FH患者中，血小板功能可能会被激活；然而，这种激活的程度及其病因尚不清楚。我们旨在评估FH患者血小板活化标志物平均血小板体积（MPV）。研究组由164例FH患者和160例对照患者组成。对照组在年龄、性别、高血压和吸烟方面进行了匹配。FH患者的MPV显著高于对照组（分别为9.2±0.4与7.9±0.6 fL；P<.001）。与对照患者相比，FH患者的血小板计数显著更低（分别为259±51与272±56×10³/L；P =.03）。在线性回归分析中，MPV仅与总胆固醇独立相关（β =.6，95%置信区间：0.004 - 0.008，P<.001）。我们已经表明，FH患者的MPV升高，并且它与总胆固醇水平独立相关。
