Dixit Siddharth, Khan Shahbaj A, Azad Sudip
Classified Specialist, Department of Psychiatry, Base Hospital Delhi Cantt , New Delhi, India .
Resident, Department of Psychiatry, Base Hospital Delhi Cantt , New Delhi, India .
J Clin Diagn Res. 2015 Feb;9(2):VD01-VD02. doi: 10.7860/JCDR/2015/11394.5583. Epub 2015 Feb 1.
Serotonin specific reuptake inhibitors (SSRI) are widely used antidepressants for variety of clinical conditions and have found popularity. They are sometimes associated with extrapyramidal side effects including Parkinsonism. We report a case of generalized anxiety disorder on treatment with SSRI (fluoxetine / sertraline) who developed irreversible Parkinsonism. SSRI are known to cause reversible or irreversible motor disturbances through pathophysiological changes in basal ganglion motor system by altering the dopamine receptors postsynaptically. Clinician should keep risk benefit ratio in mind and change of antidepressant of different class may be considered. Case is reported to alert physicians to possibility of motor system damage while treating with SSRI.
血清素特异性再摄取抑制剂（SSRI）是广泛用于治疗各种临床病症的抗抑郁药，且颇受欢迎。它们有时会伴有锥体外系副作用，包括帕金森症。我们报告一例接受SSRI（氟西汀/舍曲林）治疗的广泛性焦虑症患者，该患者出现了不可逆的帕金森症。已知SSRI通过改变基底神经节运动系统的多巴胺受体突触后病理生理变化，导致可逆或不可逆的运动障碍。临床医生应牢记风险效益比，并可考虑更换不同类别的抗抑郁药。报告此病例是为了提醒医生在使用SSRI治疗时注意运动系统受损的可能性。
