天然化合物诃子鞣酸抑制血管内皮生长因子A介导的内皮细胞功能调节。
The natural compound chebulagic acid inhibits vascular endothelial growth factor A mediated regulation of endothelial cell functions.
作者信息
Lu Kai, Basu Sujit
机构信息
Department of Pathology, Ohio State University, Columbus, Ohio 43210, United States of America.
1] Department of Pathology, Ohio State University, Columbus, Ohio 43210, United States of America [2] Division of Medical Oncology, Department of Internal Medicine, Ohio State University, Columbus, Ohio 43210, United States of America.
出版信息
Sci Rep. 2015 Apr 10;5:9642. doi: 10.1038/srep09642.
Vascular endothelial growth factor A (VEGFA) plays an important role in tumour angiogenesis and its angiogenic action is mainly mediated through its VEGF receptor 2 (VEGFR-2). Therefore drugs targeting VEGFA/VEGFR-2 are being presently used in the clinics for treatment of several types of solid malignant tumours. We here in report that low dose of chebulagic acid (CA), a hydrolysable tannin found in myrobalan fruits can inhibit VEGFA induced vascular permeability, endothelial cell proliferation, migration, tube formation and thereby, angiogenesis by suppressing VEGFR-2 phosphorylation. CA may thus be an effective and useful natural inhibitor of VEGFA mediated angiogenesis.
血管内皮生长因子A（VEGFA）在肿瘤血管生成中起重要作用，其血管生成作用主要通过其血管内皮生长因子受体2（VEGFR - 2）介导。因此，目前临床上正在使用靶向VEGFA/VEGFR - 2的药物来治疗几种类型的实体恶性肿瘤。我们在此报告，低剂量的诃子酸（CA），一种在诃子果实中发现的可水解单宁，可通过抑制VEGFR - 2磷酸化来抑制VEGFA诱导的血管通透性、内皮细胞增殖、迁移、管腔形成，从而抑制血管生成。因此，CA可能是VEGFA介导的血管生成的一种有效且有用的天然抑制剂。
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