Department of Pathology, Ohio State University, Columbus, Ohio, United States of America.
PLoS One. 2012;7(8):e43934. doi: 10.1371/journal.pone.0043934. Epub 2012 Aug 24.
Triphala churna (THL) is a combination of three fruits that has been used for many years in India for the treatment of various diseases. There are now reports which indicate that THL can inhibit growth of malignant tumors in animals. However, the mechanisms by which THL mediates its anti-tumor actions are still being explored. Because vascular endothelial growth factor-A (VEGF) induced angiogenesis plays a critical role in the pathogenesis of cancer, we therefore investigated whether tumor inhibitory effects of THL or its active constituents are through suppression of VEGF actions. We herein report that THL and chebulinic (CI) present in THL can significantly and specifically inhibit VEGF induced angiogenesis by suppressing VEGF receptor-2 (VEGFR-2) phosphorylation. These results are of clinical significance as these inexpensive and non-toxic natural products can be used for the prevention and treatment of diseases where VEGF induced angiogenesis has an important role.
三果散（THL）是由三种水果组成的混合物，在印度已经使用多年来治疗各种疾病。现在有报道表明，THL 可以抑制动物恶性肿瘤的生长。然而，THL 介导其抗肿瘤作用的机制仍在探索中。由于血管内皮生长因子-A（VEGF）诱导的血管生成在癌症的发病机制中起着关键作用，因此我们研究了 THL 或其活性成分是否通过抑制 VEGF 作用来抑制肿瘤。我们在此报告，THL 和 CHEBULINIC（CI）在 THL 中存在，可以通过抑制 VEGF 受体-2（VEGFR-2）磷酸化，显著且特异性地抑制 VEGF 诱导的血管生成。这些结果具有临床意义，因为这些廉价且无毒的天然产物可用于预防和治疗 VEGF 诱导的血管生成起重要作用的疾病。
