Clin Chem Lab Med. 2015 Apr;53(5):823-7. doi: 10.1515/cclm-2014-0699.
Red cell distribution width (RDW) is a routinely examined parameter with the complete blood count. In recent studies, RDW levels have been associated with cardiovascular, liver and renal diseases and solid tumors. The aim of this study was to evaluate the alterations of RDW levels in benign and malignant causes of postmenopausal bleeding and to investigate the association of RDW levels with clinicopathological parameters of endometrial cancer (EC) patients.
A retrospective study was made of a total of 884 females who were admitted to hospital for postmenopausal bleeding between May 2009 and December 2013. After inclusion and exclusion criteria were applied, 222 patients remained. Complete blood count data was obtained from the recorded computerized database. After pathological evaluation, the patients were divided into two groups, benign and malignant (EC).
The EC group (n=113) had significantly higher RDW levels compared to the benign group (14.78±2.02 vs. 13.88±1.05; p=0.000). Grade II and above EC patients had higher levels of RDW than Grade I patients (15.2±2.3 vs. 14.1±1.00; p=0.005). Correlation analyses also revealed a negative correlation between RDW and hemoglobin levels (p=0.000), RDW and mean corpuscular volume (p=0.000), RDW and lymphocyte count (p=0.035) but a positive correlation between RDW and platelet to lymphocyte ratio (p=0.030).
The results of the current study revealed the potential predicitve role of RDW in patients with postmenopausal bleeding. Significant associations were also determined between RDW and clinicopathological characteristics in EC patients.
红细胞分布宽度（RDW）是全血细胞计数中常规检查的参数。最近的研究表明，RDW 水平与心血管、肝脏和肾脏疾病以及实体肿瘤有关。本研究旨在评估 RDW 水平在绝经后出血的良性和恶性病因中的变化，并探讨 RDW 水平与子宫内膜癌（EC）患者临床病理参数的关系。
对 2009 年 5 月至 2013 年 12 月因绝经后出血住院的 884 名女性进行了回顾性研究。应用纳入和排除标准后，共有 222 名患者被纳入研究。从记录的计算机数据库中获得全血细胞计数数据。经病理评估后，患者分为良性和恶性两组（EC）。
EC 组（n=113）的 RDW 水平明显高于良性组（14.78±2.02 与 13.88±1.05；p=0.000）。II 级及以上 EC 患者的 RDW 水平高于 I 级患者（15.2±2.3 与 14.1±1.00；p=0.005）。相关分析还显示，RDW 与血红蛋白水平呈负相关（p=0.000），RDW 与平均红细胞体积呈负相关（p=0.000），RDW 与淋巴细胞计数呈负相关（p=0.035），但与血小板与淋巴细胞比值呈正相关（p=0.030）。
本研究结果表明，RDW 在绝经后出血患者中具有潜在的预测作用。RDW 与 EC 患者的临床病理特征之间也存在显著关联。
