Aleksandrowicz J, Wysokińska T
Med Dosw Mikrobiol. 1989;41(2):135-40.
The aim of this study was to observe aluminium hydroxide distribution in mice given this substance subcutaneously and intraperitoneally in various concentrations (0.03 mg-0.8 mg of Al3+ per dose). Each experimental group consisted of 5-6 mice of which brain, liver and kidney were isolated after 7, 14, 28, and 35 days after injection. Control group was composed of unvaccinated mice. Sera of animals vaccinated subcutaneously with the following doses: 0.2 mg, 0.4 mg and 0.8 mg were also tested. A distinct accumulation of Al3+ in liver after intraperitoneal injection with a tendency of rising after 28 days of observation was seen. The same was observed in kidneys after subcutaneous injection, especially doses of 0.4 mg Al3+ and 0.8 mg Al3+. The aluminium content in sera was high in an early period of observation only, and subsequently its elimination was fast.
本研究的目的是观察给予不同浓度（每剂0.03毫克 - 0.8毫克Al3+）的氢氧化铝皮下和腹腔注射后在小鼠体内的分布情况。每个实验组由5 - 6只小鼠组成，在注射后7、14、28和35天分离其脑、肝和肾。对照组由未接种疫苗的小鼠组成。还检测了皮下接种以下剂量：0.2毫克、0.4毫克和0.8毫克的动物血清。腹腔注射后在肝脏中观察到Al3+明显蓄积，且在观察28天后有上升趋势。皮下注射后在肾脏中也观察到同样情况，尤其是0.4毫克Al3+和0.8毫克Al3+的剂量。血清中的铝含量仅在观察早期较高，随后其清除速度很快。
