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腹腔注射不同铝化合物后小鼠血液和脑内铝的浓度

Blood and brain aluminium concentrations in mice after intra-pertioneal injection of different aluminium compounds.

作者信息

Leblondel G, Allain P

出版信息

Res Commun Chem Pathol Pharmacol. 1980 Mar;27(3):579-86.

PMID:7384646
Abstract

Aluminium chloride, nitrate, lactate and gluconate was injected by intraperitoneal route to mice at equimolecular doses, equivalent to 54 and 5.4 mg/kg of metal. The blood aluminium concentrations were increased to very high values with gluconate (99.5 mg/l) to high values with lactate (4.5 mg/l) and to low values with nitrate and chloride (0.3 mg/l). Brain aluminium concentration was increased only with glutconate at the dose of 54 mg/kg. The quantity of aluminium found in blood and brain after intraperitoneal administration at equimolecular doses is very dependent of the preparation of aluminium used.

摘要

将氯化铝、硝酸铝、乳酸铝和葡萄糖酸铝以等分子剂量通过腹腔注射途径给予小鼠,相当于54和5.4毫克/千克金属。血液铝浓度用葡萄糖酸铝时升至非常高的值(99.5毫克/升),用乳酸铝时升至高值(4.5毫克/升),用硝酸盐和氯化物时升至低值(0.3毫克/升)。仅在剂量为54毫克/千克的葡萄糖酸铝作用下,脑铝浓度才会升高。等分子剂量腹腔给药后,血液和脑中发现的铝量非常依赖于所使用的铝制剂。

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Blood and brain aluminium concentrations in mice after intra-pertioneal injection of different aluminium compounds.腹腔注射不同铝化合物后小鼠血液和脑内铝的浓度
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