State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
Cytokine Growth Factor Rev. 2015 Jun;26(3):379-87. doi: 10.1016/j.cytogfr.2015.03.001. Epub 2015 Apr 1.
Ubiquitin is a versatile molecular signature that modulates diverse cellular processes via proteasome-dependent and proteasome-independent mechanisms. The covalent and/or non-covalent binding of mono-ubiquitin and/or poly-ubiquitin chains to a target protein broadens the dynamic and functional spectra for signal integration. Different linkages of poly-ubiquitin chains determine specific physiological or pathological functions of target proteins. Accumulating evidences has revealed the essential roles of ubiquitination in orchestrating the host defenses against cytosolic RNA or DNA from viral infections. In this review, we summarize the current progress regarding the understanding of ubiquitin-mediated regulation of the RIG-I and STING antiviral signaling pathways and discuss certain critical issues that remain to be resolved in future studies.
泛素是一种多功能的分子标记物，通过蛋白酶体依赖和非依赖的机制调节多种细胞过程。单泛素和/或多泛素链与靶蛋白的共价和/或非共价结合拓宽了信号整合的动态和功能谱。多泛素链的不同连接决定了靶蛋白的特定生理或病理功能。越来越多的证据表明泛素化在协调宿主防御病毒感染的细胞质 RNA 或 DNA 方面起着至关重要的作用。在这篇综述中，我们总结了目前关于泛素介导的 RIG-I 和 STING 抗病毒信号通路调节的理解进展，并讨论了未来研究中仍需解决的一些关键问题。
