Yang Chen, Zhang Jia-Rui, Chen Lei, Ge Shun-Nan, Wang Jue-Lei, Yan Zhi-Qiang, Jia Dong, Zhu Jun-Ling, Gao Guo-Dong
Department of Neurosurgery, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, People's Republic of China.
Department of Pathology, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, People's Republic of China.
Neurosci Lett. 2015 May 19;595:122-7. doi: 10.1016/j.neulet.2015.04.011. Epub 2015 Apr 8.
Many studies showed that abnormal oscillations in the cortical-basal ganglia loop is involved in the pathophysiology of Parkinson's disease (PD). In contrast to the well-studied beta synchronization, high-voltage spindles (HVSs), another type of abnormal oscillation observed in PD, are neglected. To explore the role of subthalamic nucleus-deep brain stimulation (STN-DBS) in HVSs regulation, we simultaneously recorded the local field potential (LFP) in the globus pallidus (GP) and electrocorticogram (ECoG) in the primary motor cortex(M1) in freely moving 6-hydroxydopamine (6-OHDA) lesioned or control rats before, during, and after STN-DBS. Consistent with our previous study, HVSs occurrence, duration, and relative power and coherence between the M1 cortex and GP increased in 6-OHDA lesioned rats. We found that high but not low frequency stimulation restored the abnormal HVSs activity and motor deficit. These results suggest that the STN is involved in the abnormal oscillation between the M1 cortex and GP.
许多研究表明，皮质-基底神经节环路中的异常振荡参与了帕金森病（PD）的病理生理过程。与研究充分的β同步化不同，高压纺锤波（HVSs）作为在PD中观察到的另一种异常振荡类型，却被忽视了。为了探究丘脑底核-深部脑刺激（STN-DBS）在调节HVSs中的作用，我们在自由活动的6-羟基多巴胺（6-OHDA）损伤大鼠或对照大鼠接受STN-DBS之前、期间和之后，同时记录了苍白球（GP）的局部场电位（LFP）和初级运动皮层（M1）的脑电图（ECoG）。与我们之前的研究一致，6-OHDA损伤大鼠中HVSs的出现、持续时间以及M1皮层和GP之间的相对功率和相干性均增加。我们发现高频而非低频刺激可恢复异常的HVSs活动和运动缺陷。这些结果表明，STN参与了M1皮层和GP之间的异常振荡。
