Calabri G, Salvi G, Nieri R M, Cocchi P, Lanciotti E, Comodo N, De Mayo E, Parri F, Giambalvo A, Silenzi M
Minerva Pediatr. 1989 Sep;41(9):445-8.
Research has been carried out to determine the prevalence of toxoplasma infection in 1176 women of fertile age in Florence and province for 1984 so as to calculate expected congenital foetal risk of toxoplasmosis. Prevalence proved to be 22% in women aged from 15 to 20 and 60% in the 41-45 group, with an average annual sero-conversion rate of 1.5%. As pregnancy lasts 9 months, this rate is cut by 1/4, namely it drops from 1.5% to 1.125%. Transmission of the infection from mother to foetus occurs in about 1/3 of cases. 9256 pregnancies were reported in Florence and province. The expectation was therefore 104 primary infections and 35 infected newborns of whom 11-12 clinically diagnosable at birth. The estimated rate of toxoplasmosis in pregnancy is therefore 11% for Florence and foetal infection is about 4%. Two-thirds of the newborns with toxoplasma infection are asymptomatic but, if left untreated, they may develop serious neurological and behavioural sequelae. It is therefore necessary to learn the immune state with respect to toxoplasma for all fertile women before pregnancy and study negative findings during gestation.
已开展研究以确定1984年佛罗伦萨及其省份1176名育龄妇女的弓形虫感染率，从而计算先天性胎儿弓形虫病的预期风险。结果显示，15至20岁女性的感染率为22%，41至45岁组为60%，平均年血清转化率为1.5%。由于孕期为9个月，该比率降低了1/4，即从1.5%降至1.125%。母婴感染传播约占病例的1/3。佛罗伦萨及其省份报告了9256例妊娠。因此，预期有104例初次感染，35例新生儿感染，其中11至12例在出生时可临床诊断。因此，佛罗伦萨孕期弓形虫病的估计发病率为11%，胎儿感染率约为4%。三分之二感染弓形虫的新生儿无症状，但如果不治疗，可能会出现严重的神经和行为后遗症。因此，有必要在孕前了解所有育龄妇女对弓形虫的免疫状态，并在孕期研究阴性结果。
