Mielczarek Agnieszka, Gedrange Tomasz, Michalik Joanna
Am J Dent. 2015 Feb;28(1):51-6.
To compare the effect of combinations of fluoride (F) products on remineralization of caries-like lesions.
Demineralized human enamel specimens were assessed by surface microhardness (SMH), stratified and allocated to five treatments groups: (1) Toothpaste containing 1% nano hydroxyapatite (HAP) + 1,450 ppm F; (2) Tooth mousse containing 10% casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) + 900 ppm F plus F toothpaste (1,450 ppm F as NaF); (3) F varnish containing 22,600 ppm F plus F toothpaste (1,450 ppm F as NaF); (4) F toothpaste (1,450 ppm F as NaF); and (5) placebo--distilled water (P). Each group was treated in a 21-day pH-cycling model. Groups 1, 4 and 5 were treated 2x/day. In Group 3, the tooth mousse was administered 1x/day plus 2x/day F toothpaste treatment. In Group 4, F varnish was administered 1x/week plus 2x/day treatment with F toothpaste. After cycling, SMH was re-measured and cross-sectional microhardness measurements were taken.
Groups 1-4 produced significant rehardening of enamel. In the superficial layer (25-50 μm deep) significantly higher mineralization (up to 83%, by Volume (V), P < 0.0001) was achieved for Groups 2 and 3. In the area of 75-100 μm deep, the highest mineralization was observed for Groups 1 and 4 (V% = 68-83%).
比较氟（F）产品组合对类龋损再矿化的影响。
通过表面显微硬度（SMH）对脱矿的人牙釉质标本进行评估，将其分层并分配到五个治疗组：（1）含1%纳米羟基磷灰石（HAP）+1450 ppm F的牙膏；（2）含10%酪蛋白磷酸肽 - 无定形磷酸钙（CPP - ACP）+900 ppm F的护齿泡沫加含氟牙膏（1450 ppm F以氟化钠形式存在）；（3）含22600 ppm F的氟漆加含氟牙膏（1450 ppm F以氟化钠形式存在）；（4）含氟牙膏（1450 ppm F以氟化钠形式存在）；以及（5）安慰剂——蒸馏水（P）。每组在21天的pH循环模型中进行处理。第1、4和5组每天处理2次。在第3组中，护齿泡沫每天使用1次加含氟牙膏每天处理2次。在第4组中，氟漆每周使用1次加含氟牙膏每天处理2次。循环结束后，重新测量表面显微硬度并进行横断面显微硬度测量。
第1 - 4组牙釉质产生了显著的再硬化。在表层（25 - 50μm深），第2组和第3组实现了显著更高的矿化（体积分数（V）高达83%，P < 0.0001）。在75 - 100μm深的区域，第1组和第4组观察到最高的矿化（V% = 68 - 83%）。
