La Torre R, Bevilacqua E, D'Ambrosio V, Pasquali G, Aliberti C, Perrone G, Giancotti A
Clin Exp Obstet Gynecol. 2014;41(5):599-600.
The only prostaglandin analogue licensed in Italy for induction of labour in spontaneous and therapeutic abortion is gemeprost. The authors report a case of spontaneous uterine rupture of a scarred uterus, for previous caesarean sections, in a woman at 20 weeks of gestation with a diagnosis of spontaneous abortion. She received a pessary of gemeprost every three hours. After the fifth pessary, she complained of severe pain. At the ultrasound examination, uterine cavity appeared empty and the dead fetus was dislocated in the abdomen. Emergency laparotomy was performed and uterine tear was repaired. To induce labour for fetal demise or therapeutic abortion in second trimester in women with scarred uterus, the authors decided to lengthen the time between administrations of pessary from four to five hours depending on patient's symptoms. However the appropriate drug regimen has still to be found and more data are necessary.
在意大利，唯一被批准用于自然流产和治疗性流产引产的前列腺素类似物是吉美前列素。作者报告了一例有剖宫产史的瘢痕子宫孕妇，妊娠20周时诊断为自然流产，发生自发性子宫破裂的病例。她每三小时接受一次吉美前列素栓剂。在使用第五枚栓剂后，她诉说剧痛。超声检查显示子宫腔空虚，死胎位于腹腔。遂行急诊剖腹手术并修复子宫撕裂处。对于瘢痕子宫孕妇孕中期因胎儿死亡或治疗性流产而行引产时，作者决定根据患者症状将栓剂给药间隔时间从4小时延长至5小时。然而，仍需找到合适的药物方案，且需要更多数据。
