Thong K J, Baird D T
Department of Obstetrics and Gynaecology, University of Edinburgh, Scotland.
Acta Obstet Gynecol Scand. 1992 Apr;71(3):191-6. doi: 10.3109/00016349209009917.
Two regimens of the prostaglandin E1 analogue, gemeprost, were compared in an open trial for termination of pregnancy between 12 and 18 weeks. Fifty women received 5 x 1 mg of gemeprost every 3 h and in another 50 cases, 4 x 1 mg of gemeprost was administered every 6 h. Although the median abortion interval was slightly shorter in the 3-hourly group (15.9 h vs. 16.9 h; p = 0.5), the cumulative abortion rates at 24 h were similar (88% vs. 82%; p less than 0.5). In women who aborted within the first 24 h, significantly fewer pessaries (p less than 0.01) were required to induce abortion in the 6-h treatment group (median 3, range 1-4) than the 3-h group (median 5, 2-5). Parous women in both treatment groups required fewer pessaries to induce abortion than did nulliparous women (not significant; p = 0.5). Significantly (p less than 0.01) fewer pessaries were required to induce abortion in the 6-h gemeprost group. The were no significant differences between the groups regarding incidences of diarrhea, vomiting, or the request for analgesia. These results suggest that in many women the number of pessaries used to induce mid-trimester abortion could be reduced by lengthening the interval between insertion of pessaries within the first 24 h, without loss of clinical efficacy.
在一项关于终止12至18周妊娠的开放性试验中，对两种前列腺素E1类似物吉美前列素的给药方案进行了比较。50名妇女每3小时接受5次1毫克的吉美前列素，另外50例每6小时给予4次1毫克的吉美前列素。虽然每3小时给药组的中位流产间隔略短（15.9小时对16.9小时；p = 0.5），但24小时时的累积流产率相似（88%对82%；p小于0.5）。在24小时内流产的妇女中，6小时治疗组诱导流产所需的阴道栓剂明显更少（p小于0.01）（中位值3，范围1 - 4），低于每3小时给药组（中位值5，2 - 5）。两个治疗组中的经产妇诱导流产所需的阴道栓剂均比未产妇少（无显著性差异；p = 0.5）。6小时吉美前列素组诱导流产所需的阴道栓剂明显更少（p小于0.01）。两组在腹泻、呕吐发生率或镇痛需求方面无显著差异。这些结果表明，对于许多妇女来说，在妊娠中期诱导流产时，可通过延长前24小时内阴道栓剂的放置间隔来减少所用阴道栓剂的数量，且不影响临床疗效。
