Peltzer Karl, Phaswana-Mafuya Nancy
Afr J AIDS Res. 2008 Jul;7(2):209-18. doi: 10.2989/AJAR.2008.7.2.6.523.
The study aims to assess the health-related quality of life and HIV symptoms of a sample of people living with HIV (PLHIV) in South Africa. The sample included 607 PLHIV from all districts of the Eastern Cape Province, recruited either through a health facility, from the community through key informants, or through support groups. At the time of the study, 66% of the respondents reported having been given an AIDS diagnosis (advanced stage of HIV disease), 48% were on antiretroviral therapy (ART), and 35% were receiving a disability grant. The findings indicate a low degree of overall quality of life, with a mean score of 13.4 on the WHOQOL-HIV measure. Among the WHOQOL-HIV BREF subscales, logistic regression identified spirituality, environment, psychological health, and level of independence as predictors for overall quality of life. Among medical variables and HIV symptoms, CD4 cell count and having fewer HIV symptoms but not an AIDS diagnosis were identified as predictors for overall quality of life; among socio-economic variables, having sufficient food and a higher educational level were identified as predictors. The results highlight the need for better access to psychosocial support and medical services for PLHIV in South Africa, as well as the need to consider a patient's general health perceptions during the course of ART.
该研究旨在评估南非一部分艾滋病毒感染者（PLHIV）的健康相关生活质量和艾滋病毒症状。样本包括来自东开普省所有地区的607名艾滋病毒感染者，他们通过医疗机构、通过关键信息提供者从社区招募，或通过支持小组招募。在研究时，66%的受访者报告已被诊断为艾滋病（艾滋病毒疾病晚期），48%正在接受抗逆转录病毒治疗（ART），35%正在领取残疾补助金。研究结果表明总体生活质量较低，在世界卫生组织艾滋病毒生活质量量表（WHOQOL-HIV）上的平均得分为13.4。在WHOQOL-HIV简表各维度中，逻辑回归确定精神性、环境、心理健康和独立程度是总体生活质量的预测因素。在医学变量和艾滋病毒症状方面，CD4细胞计数以及艾滋病毒症状较少但未被诊断为艾滋病被确定为总体生活质量的预测因素；在社会经济变量方面，有足够的食物和较高的教育水平被确定为预测因素。结果强调了南非的艾滋病毒感染者需要更好地获得心理社会支持和医疗服务，以及在抗逆转录病毒治疗过程中考虑患者总体健康认知的必要性。
