Alemán Mercedes
IMEX-CONTICET-ANM, Buenos Aires, Argentina.
Tuberculosis (Edinb). 2015 Jul;95(4):359-63. doi: 10.1016/j.tube.2015.03.010. Epub 2015 Mar 31.
Polymorphonuclear neutrophils comprise two-thirds of peripheral blood leukocytes and are key components of innate immunity as a first line of defense against bacterial and fungal pathogens. Their microbicidal mechanisms are essential for bacterial killing, the enhancement of inflammatory reactions and also comprise signaling molecules which have been implicated in signal transduction cascades. In tuberculosis, the number of neutrophils increases in the affected lung. In addition, they become activated and apoptotic due the bacterial burden. As apoptosis is promoted by reactive oxygen species (ROS) during phagocytosis, the advantages and benefits to the host as well as the strategies displayed by the pathogen to avoid or retard apoptosis are discussed in this review.
多形核中性粒细胞占外周血白细胞的三分之二，作为抵御细菌和真菌病原体的第一道防线，是固有免疫的关键组成部分。它们的杀菌机制对于杀灭细菌、增强炎症反应至关重要，还包含参与信号转导级联反应的信号分子。在结核病中，受累肺部的中性粒细胞数量会增加。此外，由于细菌负荷，它们会被激活并发生凋亡。由于吞噬过程中活性氧（ROS）会促进细胞凋亡，本综述将讨论细胞凋亡对宿主的利弊以及病原体为避免或延缓细胞凋亡所采取的策略。
