Faridgohar Majid, Nikoueinejad Hassan
a Molecular Biology Research Center , Baqiyatallah University of Medical Sciences , Tehran , Iran.
b Nephrology and Urology Research Center , Baqiyatallah University of Medical Sciences , Tehran , Iran.
Pathog Glob Health. 2017 Jul;111(5):256-264. doi: 10.1080/20477724.2017.1351080. Epub 2017 Jul 17.
Tuberculosis (TB), an important issue in the present age, affects millions of people each year. The infectious agent of TB, Mycobacterium tuberculosis (Mtb), interacts with the immune system which prevents the development of this bacterium as much as possible. In fact, the receptors on the surface of immune cells identify the bacteria, one of which is Toll-like receptors (TLRs). Different TLRs including 2, 4, 9 and 8 play critical roles in tuberculosis infection. In this paper, we focused on the role of TLRs which interact with different components of Mtb and, consequently, prevent the entrance and influence of bacteria on the body.
结核病（TB）是当代一个重要问题，每年影响数百万人。结核病的病原体结核分枝杆菌（Mtb）与免疫系统相互作用，免疫系统会尽可能阻止这种细菌的发展。事实上，免疫细胞表面的受体能够识别细菌，其中之一是Toll样受体（TLRs）。包括2、4、9和8在内的不同TLRs在结核病感染中发挥着关键作用。在本文中，我们重点关注了TLRs的作用，它们与Mtb的不同成分相互作用，从而阻止细菌进入人体并对身体产生影响。
