p53、mgmt及egfr在脑胶质瘤中的表达及临床意义

The expression of p53, mgmt and egfr in brain glioma and clinical significance.

作者信息

Lin T, Wang M, Liang H S, Liu E Z

机构信息

Key Laboratory of Neurosurgery, College of Heilongjiang Province, First Affiliated Hospital of Harbin Medical University, Harbin, China.

Department of Oncology, the Tumour Hospital of Harbin Medical University, Harbin, China.

出版信息

J Biol Regul Homeost Agents. 2015 Jan-Mar;29(1):143-9.

PMID:25864751

Abstract

In order to discuss the expression of P53, MGMT (O6-methylguanine-DNA methyltransferase) and EGFR (epidermal growth factor receptor) in brain glioma and their clinical significance, this paper collected clinical features of 40 patients. We observed the expression of P53, MGMT and EGFR in samples using immuohisto-chemistry assay and analyzed their interaction, as well as their relationship to brain glioma. It was found that among 40 cases of brain glioma samples, cases with positive P53 expression accounted for 47.5%, and its expression in high-grade brain glioma was higher than in low-grade brain glioma (P less than 0.05); cases with positive MGMT expression accounted for 37.5%;, and its expression in high-grade glioma and low-grade brain glioma had no statistical significance (P>0.05); cases with positive EGFR expression accounted for 55%, and its expression in high-grade brain glioma was higher than in low-grade brain glioma (P less than 0.05); the expression of P53, MGMT and EGFT were not correlated to age, gender or size of tumor; P53 expression was negatively correlated to MGMT expression (P < 0.05) but positively correlated to EGFR expression (P < 0.05) demonstration that P53, EGFR and MGMT play important roles in the occurrence and development of brain glioma.

摘要

为探讨P53、O6-甲基鸟嘌呤-DNA甲基转移酶（MGMT）和表皮生长因子受体（EGFR）在脑胶质瘤中的表达情况及其临床意义，本文收集了40例患者的临床资料。采用免疫组织化学法观察样本中P53、MGMT和EGFR的表达情况，并分析它们之间的相互作用以及与脑胶质瘤的关系。结果发现，在40例脑胶质瘤样本中，P53表达阳性的病例占47.5%，其在高级别脑胶质瘤中的表达高于低级别脑胶质瘤（P<0.05）；MGMT表达阳性的病例占37.5%，其在高级别胶质瘤和低级别脑胶质瘤中的表达无统计学意义（P>0.05）；EGFR表达阳性的病例占55%，其在高级别脑胶质瘤中的表达高于低级别脑胶质瘤（P<0.05）；P53、MGMT和EGFR的表达与患者年龄、性别及肿瘤大小无关；P53表达与MGMT表达呈负相关（P<0.05），但与EGFR表达呈正相关（P<0.05），表明P53、EGFR和MGMT在脑胶质瘤的发生发展中起重要作用。