Lipari L, Gerbino A, Lipari A, Barone R, Farina E
Department of Experimental Biomedicine and Clinical Neurosciences (BioNeC), University of Palermo, Italy.
J Biol Regul Homeost Agents. 2015 Jan-Mar;29(1):235-8.
This immunohistochemical study aims to investigate the Atrial natriuretic peptide (ANP)-presence and localization in human articular cartilage. Fragments of articular cartilage covering the femoral head were removed from patients submitted to surgical operation after femoral neck fracture without joint disease. The samples were immunostained with anti-ANP antibody. The results demonstrate that ANP is present in chondrocytes in all the three zones of the articular cartilage. Superficial chondrocytes show strong ANP-immunopositivty. The presence of ANP in the articular cartilage suggests that ANP may play a role in cartilage metabolism by regulating transport of molecules through the different zones of the articular cartilage and in maintenance of its homeostasis; probably ANP could be also involved in the regulation of the balance between synovial fluid and the other body fluids.
本免疫组织化学研究旨在调查心房利钠肽（ANP）在人体关节软骨中的存在情况和定位。从无关节疾病的股骨颈骨折手术后接受手术的患者身上取出覆盖股骨头的关节软骨碎片。样本用抗ANP抗体进行免疫染色。结果表明，ANP存在于关节软骨所有三个区域的软骨细胞中。表层软骨细胞显示出强烈的ANP免疫阳性。关节软骨中ANP的存在表明，ANP可能通过调节分子在关节软骨不同区域的运输以及维持其稳态来参与软骨代谢；ANP可能还参与滑膜液与其他体液之间平衡的调节。
