Sarthy P V, Fu M, Huang J
Department of Ophthalmology, Physiology and Biophysics, University of Washington, Seattle 98195.
Mol Cell Biol. 1989 Oct;9(10):4556-9. doi: 10.1128/mcb.9.10.4556-4559.1989.
Eucaryotic mRNAs are generally localized in the cell body, where most protein synthesis occurs. We have found that mRNAs encoding the glial intermediate filament protein are spatially distributed in the glial cell cytoplasm close to the location of the glial filaments. Whereas the glial filament protein mRNA was located predominantly in the distal process, actin mRNA was found almost exclusively in the apical portion of the glial cell. This pattern of mRNA localization might provide a mechanism for synthesis of proteins in specific subcellular compartments by mRNA translation locally.
真核生物的信使核糖核酸（mRNA）通常定位于细胞体，而大多数蛋白质合成在此发生。我们发现，编码神经胶质中间丝蛋白的mRNA在神经胶质细胞的细胞质中呈空间分布，靠近神经胶质丝的位置。神经胶质丝蛋白mRNA主要位于远端突起，而肌动蛋白mRNA几乎只在神经胶质细胞的顶端部分被发现。这种mRNA定位模式可能为通过局部mRNA翻译在特定亚细胞区室中合成蛋白质提供一种机制。
