McAnerney Johanna M, Treurnicht Florette, Walaza Sibongile, Cohen Adam L, Tempia Stefano, Mtshali Senzo, Buys Amelia, Blumberg Lucille, Cohen Cheryl
National Institute for Communicable Diseases (NICD) , National Health laboratory services (NHLS), Johannesburg, South Africa.
School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Influenza Other Respir Viruses. 2015 Jul;9(4):209-15. doi: 10.1111/irv.12314.
The effectiveness of the trivalent seasonal influenza vaccine during the 2014 season in South Africa was assessed using a test-negative case-control study design including 472 cases and 362 controls. Influenza A(H3N2) was the dominant strain circulating. The overall vaccine effectiveness estimate, adjusted for age and underlying conditions, was 43·1% (95% CI: -26·8-74·5). 2014 H3N2 viruses from South Africa were mainly in sublineage 3C.3 with accumulation of amino acid changes that differentiate them from the vaccine strain in 3C.1.
采用检测呈阴性的病例对照研究设计，对2014年南非三价季节性流感疫苗的有效性进行了评估，该研究包括472例病例和362例对照。甲型（H3N2）流感是主要流行毒株。经年龄和基础疾病调整后的总体疫苗有效性估计值为43.1%（95%可信区间：-26.8-74.5）。来自南非的2014年H3N2病毒主要属于3C.3亚谱系，积累了一些氨基酸变化，使其与3C.1中的疫苗毒株有所不同。
