2014年南非门诊环境中流感疫苗效果评估及流行毒株描述
Evaluation of influenza vaccine effectiveness and description of circulating strains in outpatient settings in South Africa, 2014.
作者信息
McAnerney Johanna M, Treurnicht Florette, Walaza Sibongile, Cohen Adam L, Tempia Stefano, Mtshali Senzo, Buys Amelia, Blumberg Lucille, Cohen Cheryl
机构信息
National Institute for Communicable Diseases (NICD) , National Health laboratory services (NHLS), Johannesburg, South Africa.
School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
出版信息
Influenza Other Respir Viruses. 2015 Jul;9(4):209-15. doi: 10.1111/irv.12314.
The effectiveness of the trivalent seasonal influenza vaccine during the 2014 season in South Africa was assessed using a test-negative case-control study design including 472 cases and 362 controls. Influenza A(H3N2) was the dominant strain circulating. The overall vaccine effectiveness estimate, adjusted for age and underlying conditions, was 43·1% (95% CI: -26·8-74·5). 2014 H3N2 viruses from South Africa were mainly in sublineage 3C.3 with accumulation of amino acid changes that differentiate them from the vaccine strain in 3C.1.
采用检测呈阴性的病例对照研究设计，对2014年南非三价季节性流感疫苗的有效性进行了评估，该研究包括472例病例和362例对照。甲型（H3N2）流感是主要流行毒株。经年龄和基础疾病调整后的总体疫苗有效性估计值为43.1%（95%可信区间：-26.8-74.5）。来自南非的2014年H3N2病毒主要属于3C.3亚谱系，积累了一些氨基酸变化，使其与3C.1中的疫苗毒株有所不同。
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