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流感病毒的演变及H3N2疫苗的有效性，应用于2014/2015季节。

Influenza evolution and H3N2 vaccine effectiveness, with application to the 2014/2015 season.

作者信息

Li Xi, Deem Michael W

机构信息

Department of Bioengineering, Rice University, Houston, TX 77005, USA.

Department of Bioengineering, Rice University, Houston, TX 77005, USA Department of Physics and Astronomy, Rice University, Houston, TX 77005, USA Center for Theoretical Biological Physics, Rice University, Houston, TX 77005, USA

出版信息

Protein Eng Des Sel. 2016 Aug;29(8):309-15. doi: 10.1093/protein/gzw017. Epub 2016 Jun 16.

DOI:10.1093/protein/gzw017
PMID:27313229
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4955871/
Abstract

Influenza A is a serious disease that causes significant morbidity and mortality, and vaccines against the seasonal influenza disease are of variable effectiveness. In this article, we discuss the use of the pepitope method to predict the dominant influenza strain and the expected vaccine effectiveness in the coming flu season. We illustrate how the effectiveness of the 2014/2015 A/Texas/50/2012 [clade 3C.1] vaccine against the A/California/02/2014 [clade 3C.3a] strain that emerged in the population can be estimated via pepitope In addition, we show by a multidimensional scaling analysis of data collected through 2014, the emergence of a new A/New Mexico/11/2014-like cluster [clade 3C.2a] that is immunologically distinct from the A/California/02/2014-like strains.

摘要

甲型流感是一种会导致严重发病和死亡的严重疾病，针对季节性流感疾病的疫苗效果参差不齐。在本文中，我们讨论了使用肽表位方法来预测即将到来的流感季节中占主导地位的流感毒株以及预期的疫苗效果。我们举例说明了如何通过肽表位估计2014/2015年A/德克萨斯/50/2012[3C.1分支]疫苗针对人群中出现的A/加利福尼亚/02/2014[3C.3a分支]毒株的有效性。此外，通过对2014年收集的数据进行多维标度分析，我们表明出现了一个新的A/新墨西哥/11/2014样簇[3C.2a分支]，它在免疫学上与A/加利福尼亚/02/2014样毒株不同。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3356/4955871/4695c249e36f/gzw01704.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3356/4955871/98307a9869f6/gzw01701.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3356/4955871/aed1bb6fc0e7/gzw01703.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3356/4955871/4695c249e36f/gzw01704.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3356/4955871/98307a9869f6/gzw01701.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3356/4955871/aed1bb6fc0e7/gzw01703.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3356/4955871/4695c249e36f/gzw01704.jpg

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