Slijper F M, Huisman J, Hendrikx M M, Kalverboer A F, van der Schot L
Abteilung Kinderpsychiatrie, Sophia Kinder Ziekenhuis, Rotterdam.
Monatsschr Kinderheilkd. 1989 Oct;137(10):662-5.
Since 1st September 1974 almost all newborns in The Netherlands have been screened for phenylketonuria (PKU). Data collected between then and 1 October 1984 are presented, with respect to the intellectual functioning of 69 patients who received early treatment for PKU. Wherever possible, psychological testing was carried out at four key ages, namely 1.0 years, 2.0 years, 4.6 years, 6.6 years. The results of the tests revealed no differences in the mental levels of these patients and healthy children at any of the key ages. Also no sex differences at key ages 1 and 2 years related to this variable were found. The longitudinal course of the intellectual development in the first four and a half years was stable. The necessity for the continuation of screening and the collection of psychosocial data is discussed.
自1974年9月1日起，荷兰几乎所有新生儿都接受了苯丙酮尿症（PKU）筛查。本文呈现了1974年9月1日至1984年10月1日期间收集的数据，这些数据与69例接受早期PKU治疗患者的智力功能有关。只要有可能，就在1.0岁、2.0岁、4.6岁、6.6岁这四个关键年龄进行心理测试。测试结果显示，在任何关键年龄，这些患者与健康儿童的智力水平均无差异。在1岁和2岁这两个关键年龄，也未发现与该变量相关的性别差异。在最初的四年半时间里，智力发展的纵向过程是稳定的。文中还讨论了持续进行筛查以及收集社会心理数据的必要性。
