Matthews W S, Barabas G, Cusack E, Ferrari M
Am J Ment Defic. 1986 Jul;91(1):92-4.
The records of 16 early-treated children with phenylketonuria (PKU) whose low-phenylalanine diets had been discontinued at an average age of 5.5 years were reviewed for evidence of deterioration in functioning. Measures of their medical and social status, namely, serum phenylalanine levels and Vineland Social Quotients, before and after diet discontinuation were investigated via repeated measures analyses of variance. Social quotients decreased significantly following discontinuation and were inversely correlated with serum phenylalanine levels.
对16名苯丙酮尿症（PKU）早期接受治疗的儿童的记录进行了回顾，这些儿童在平均5.5岁时停止了低苯丙氨酸饮食，以寻找功能恶化的证据。通过重复测量方差分析，研究了他们在停止饮食前后的医学和社会状况指标，即血清苯丙氨酸水平和韦氏社会商数。停止饮食后，社会商数显著下降，且与血清苯丙氨酸水平呈负相关。
