Zarin Payam, Chen Edward L Y, In Tracy S H, Anderson Michele K, Zúñiga-Pflücker Juan Carlos
Department of Immunology, University of Toronto, and Sunnybrook Research Institute, Toronto, Ontario M4N 3M5, Canada.
Department of Immunology, University of Toronto, and Sunnybrook Research Institute, Toronto, Ontario M4N 3M5, Canada.
Cell Immunol. 2015 Jul;296(1):70-5. doi: 10.1016/j.cellimm.2015.03.007. Epub 2015 Mar 25.
γδ T-cells boast an impressive functional repertoire that can paint them as either champions or villains depending on the environmental and immunological cues. Understanding the function of the various effector γδ subsets necessitates tracing the developmental program of these subsets, including the point of lineage bifurcation from αβ T-cells. Here, we review the importance of signals from the T-cell receptor (TCR) in determining αβ versus γδ lineage fate, and further discuss how the molecular components of this pathway may influence the developmental programming of γδ T-cells functional subsets. Additionally, we discuss the role of temporal windows in restricting the development of IL-17 producing γδ T-cell subtypes, and explore whether fetal and adult hematopoietic progenitors maintain the same potential for giving rise to this important subset.
γδ T细胞具有令人印象深刻的功能谱，根据环境和免疫线索，它们既可以被描绘成“英雄”，也可以被描绘成“恶棍”。要了解各种效应γδ亚群的功能，就需要追踪这些亚群的发育程序，包括它们与αβ T细胞谱系分叉的点。在这里，我们回顾了来自T细胞受体（TCR）的信号在决定αβ与γδ谱系命运中的重要性，并进一步讨论该途径的分子成分如何影响γδ T细胞功能亚群的发育编程。此外，我们讨论了时间窗口在限制产生IL-17的γδ T细胞亚型发育中的作用，并探讨胎儿和成人造血祖细胞产生这一重要亚群的潜力是否相同。
