Taghon Tom, Rothenberg Ellen V
Department of Clinical Chemistry, Microbiology, and Immunology, Ghent University Hospital, Ghent University, De Pintelaan 185, 4 Blok A, 9000, Ghent, Belgium.
Semin Immunopathol. 2008 Dec;30(4):383-98. doi: 10.1007/s00281-008-0134-3. Epub 2008 Oct 17.
Following specification of hematopoietic precursor cells into the T cell lineage, several developmental options remain available to the immature thymocytes. The paradigm is that the outcome of the T cell receptor rearrangements and the corresponding T cell receptor signaling events will be predominant to determine the first of these choices: the alphabeta versus gammadelta T cell pathways. Here, we review the thymus-derived environmental signals, the transcriptional mediators, and other molecular mechanisms that are also involved in this decision in both the mouse and human. We discuss the differences in cellular events between the alphabeta and gammadelta developmental pathways and try to correlate these with a corresponding complexity of the molecular mechanisms that support them.
在造血前体细胞分化为T细胞谱系后，未成熟胸腺细胞仍有几种发育选择。典型的情况是，T细胞受体重排的结果以及相应的T细胞受体信号事件将在很大程度上决定这些选择中的第一个：αβ与γδ T细胞途径。在这里，我们综述了在小鼠和人类中也参与这一决定的胸腺来源的环境信号、转录调节因子和其他分子机制。我们讨论了αβ和γδ发育途径之间细胞事件的差异，并试图将这些差异与支持它们的分子机制的相应复杂性联系起来。
